Chemical modification of pseurotin A: One-pot synthesis of synerazol and pseurotin E and determination of absolute stereochemistry of pseurotin E

Minoru Ishikawa; Tomohisa Ninomiya

doi:10.1038/ja.2008.99

Chemical modification of pseurotin A: One-pot synthesis of synerazol and pseurotin E and determination of absolute stereochemistry of pseurotin E

Minoru Ishikawa, Tomohisa Ninomiya

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Two natural products, synerazol and pseurotin E, were synthesized from the natural product pseurotin A in 58% and 57% yields, respectively in one-pot procedures. This work also establishes the absolute stereochemistry of pseurotin E.

Original language	English
Pages (from-to)	692-695
Number of pages	4
Journal	Journal of Antibiotics
Volume	61
Issue number	11
DOIs	https://doi.org/10.1038/ja.2008.99
Publication status	Published - 2008 Nov
Externally published	Yes

Keywords

Absolute stereochemistry
Chemical modification
Pseurotin A
Pseurotin E
Synerazol

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2008.99

Cite this

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title = "Chemical modification of pseurotin A: One-pot synthesis of synerazol and pseurotin E and determination of absolute stereochemistry of pseurotin E",

abstract = "Two natural products, synerazol and pseurotin E, were synthesized from the natural product pseurotin A in 58% and 57% yields, respectively in one-pot procedures. This work also establishes the absolute stereochemistry of pseurotin E.",

keywords = "Absolute stereochemistry, Chemical modification, Pseurotin A, Pseurotin E, Synerazol",

author = "Minoru Ishikawa and Tomohisa Ninomiya",

year = "2008",

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T2 - One-pot synthesis of synerazol and pseurotin E and determination of absolute stereochemistry of pseurotin E

AU - Ishikawa, Minoru

AU - Ninomiya, Tomohisa

PY - 2008/11

Y1 - 2008/11

N2 - Two natural products, synerazol and pseurotin E, were synthesized from the natural product pseurotin A in 58% and 57% yields, respectively in one-pot procedures. This work also establishes the absolute stereochemistry of pseurotin E.

AB - Two natural products, synerazol and pseurotin E, were synthesized from the natural product pseurotin A in 58% and 57% yields, respectively in one-pot procedures. This work also establishes the absolute stereochemistry of pseurotin E.

KW - Absolute stereochemistry

KW - Chemical modification

KW - Pseurotin A

KW - Pseurotin E

KW - Synerazol

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Chemical modification of pseurotin A: One-pot synthesis of synerazol and pseurotin E and determination of absolute stereochemistry of pseurotin E

Abstract

Keywords

ASJC Scopus subject areas

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