Chemical structures of amphidinols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption

Gopal K. Paul; Nobuaki Matsumori; Keiichi Konoki; Michio Murata; Kazuo Tachibana

Chemical structures of amphidinols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption

Gopal K. Paul, Nobuaki Matsumori, Keiichi Konoki, Michio Murata, Kazuo Tachibana

Research output: Contribution to journal › Article › peer-review

Abstract

A series of polyhydroxy-polyene compounds were isolated from the cultured dinoflagellate Amphidinium klebsii as well as from its surrounding media. Amphidinol 5 (AM 5) and 6 (AM 6) were found to be potent antifungal and hemolytic agents. Their permeabilizing activity towards phospholipid liposomes was markedly enhanced by the presence of cholesterol within the bilayer, indicating that the mechanism of action involved interaction with membranal cholesterol.

Original language	English
Pages (from-to)	124-128
Number of pages	5
Journal	Journal of Marine Biotechnology
Volume	5
Issue number	2-3
Publication status	Published - 1997 Dec 1
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Chemical structures of amphidinols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption",

abstract = "A series of polyhydroxy-polyene compounds were isolated from the cultured dinoflagellate Amphidinium klebsii as well as from its surrounding media. Amphidinol 5 (AM 5) and 6 (AM 6) were found to be potent antifungal and hemolytic agents. Their permeabilizing activity towards phospholipid liposomes was markedly enhanced by the presence of cholesterol within the bilayer, indicating that the mechanism of action involved interaction with membranal cholesterol.",

author = "Paul, {Gopal K.} and Nobuaki Matsumori and Keiichi Konoki and Michio Murata and Kazuo Tachibana",

year = "1997",

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T1 - Chemical structures of amphidinols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption

AU - Paul, Gopal K.

AU - Matsumori, Nobuaki

AU - Konoki, Keiichi

AU - Murata, Michio

AU - Tachibana, Kazuo

PY - 1997/12/1

Y1 - 1997/12/1

N2 - A series of polyhydroxy-polyene compounds were isolated from the cultured dinoflagellate Amphidinium klebsii as well as from its surrounding media. Amphidinol 5 (AM 5) and 6 (AM 6) were found to be potent antifungal and hemolytic agents. Their permeabilizing activity towards phospholipid liposomes was markedly enhanced by the presence of cholesterol within the bilayer, indicating that the mechanism of action involved interaction with membranal cholesterol.

AB - A series of polyhydroxy-polyene compounds were isolated from the cultured dinoflagellate Amphidinium klebsii as well as from its surrounding media. Amphidinol 5 (AM 5) and 6 (AM 6) were found to be potent antifungal and hemolytic agents. Their permeabilizing activity towards phospholipid liposomes was markedly enhanced by the presence of cholesterol within the bilayer, indicating that the mechanism of action involved interaction with membranal cholesterol.

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M3 - Article

AN - SCOPUS:0001569209

SN - 0941-2905

VL - 5

SP - 124

EP - 128

JO - Journal of Marine Biotechnology

JF - Journal of Marine Biotechnology

IS - 2-3

ER -

Chemical structures of amphidinols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption

Abstract

ASJC Scopus subject areas

UN SDGs

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