Chemically Locked Bicelles with High Thermal and Kinetic Stability

Ryoichi Matsui, Masataka Ohtani, Kuniyo Yamada, Takaaki Hikima, Masaki Takata, Takashi Nakamura, Hiroyuki Koshino, Yasuhiro Ishida, Takuzo Aida

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90°C) with excellent 2H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.

Original languageEnglish
Pages (from-to)13284-13288
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number45
Publication statusPublished - 2015 Nov 1
Externally publishedYes


  • biomembranes
  • phospholipids
  • polymerization
  • surfactants
  • templated synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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