Chemically Locked Bicelles with High Thermal and Kinetic Stability

Ryoichi Matsui; Masataka Ohtani; Kuniyo Yamada; Takaaki Hikima; Masaki Takata; Takashi Nakamura; Hiroyuki Koshino; Yasuhiro Ishida; Takuzo Aida

doi:10.1002/anie.201506781

Chemically Locked Bicelles with High Thermal and Kinetic Stability

Ryoichi Matsui, Masataka Ohtani, Kuniyo Yamada, Takaaki Hikima, Masaki Takata, Takashi Nakamura, Hiroyuki Koshino, Yasuhiro Ishida, Takuzo Aida

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90°C) with excellent ²H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.

Original language	English
Pages (from-to)	13284-13288
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	45
DOIs	https://doi.org/10.1002/anie.201506781
Publication status	Published - 2015 Nov 1
Externally published	Yes

Keywords

biomembranes
phospholipids
polymerization
surfactants
templated synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201506781

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abstract = "In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90°C) with excellent 2H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.",

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T1 - Chemically Locked Bicelles with High Thermal and Kinetic Stability

AU - Matsui, Ryoichi

AU - Ohtani, Masataka

AU - Yamada, Kuniyo

AU - Hikima, Takaaki

AU - Takata, Masaki

AU - Nakamura, Takashi

AU - Koshino, Hiroyuki

AU - Ishida, Yasuhiro

AU - Aida, Takuzo

PY - 2015/11/1

Y1 - 2015/11/1

N2 - In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90°C) with excellent 2H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.

AB - In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90°C) with excellent 2H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.

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KW - phospholipids

KW - polymerization

KW - surfactants

KW - templated synthesis

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Chemically Locked Bicelles with High Thermal and Kinetic Stability

Abstract

Keywords

ASJC Scopus subject areas

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