TY - JOUR
T1 - Chemistry of puffer fish toxin
AU - Yotsu-Yamashita, M.
N1 - Funding Information:
The author thank Dr. Takeshi Yasumoto, Japan Food Research Laboratories, Professor Emeritus of Tohoku University, for critical reading of this manuscript. This work was supported by Grant-in Aid from the Ministry of Education, Science, Sports and Culture of Japan (No. 12045210), and grants from the Naito Foundation, and the Fujisawa Foundation.
PY - 2001
Y1 - 2001
N2 - Tetrodotoxin (TTX) is well known as the puffer fish toxin. Naturally occurring analogs of TTX have been isolated from puffer fish, newts and frogs, and their structures have been determined by spectroscopic methods. Additionally, TTX analogs have been prepared by chemical modification to investigate its binding site on sodium channels and the structure-activity relationship of TTX. In this article, the NMR data of TTX analogs are listed, and the chemical modification methods for preparation of TTX probes are summarized.
AB - Tetrodotoxin (TTX) is well known as the puffer fish toxin. Naturally occurring analogs of TTX have been isolated from puffer fish, newts and frogs, and their structures have been determined by spectroscopic methods. Additionally, TTX analogs have been prepared by chemical modification to investigate its binding site on sodium channels and the structure-activity relationship of TTX. In this article, the NMR data of TTX analogs are listed, and the chemical modification methods for preparation of TTX probes are summarized.
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U2 - 10.1081/TXR-100102536
DO - 10.1081/TXR-100102536
M3 - Review article
AN - SCOPUS:0035067227
SN - 1556-9543
VL - 20
SP - 51
EP - 66
JO - Journal of Toxicology - Toxin Reviews
JF - Journal of Toxicology - Toxin Reviews
IS - 1
ER -