Chemistry of puffer fish toxin

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    85 Citations (Scopus)


    Tetrodotoxin (TTX) is well known as the puffer fish toxin. Naturally occurring analogs of TTX have been isolated from puffer fish, newts and frogs, and their structures have been determined by spectroscopic methods. Additionally, TTX analogs have been prepared by chemical modification to investigate its binding site on sodium channels and the structure-activity relationship of TTX. In this article, the NMR data of TTX analogs are listed, and the chemical modification methods for preparation of TTX probes are summarized.

    Original languageEnglish
    Pages (from-to)51-66
    Number of pages16
    JournalJournal of Toxicology - Toxin Reviews
    Issue number1
    Publication statusPublished - 2001

    ASJC Scopus subject areas

    • Toxicology
    • Health, Toxicology and Mutagenesis


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