Chiral primary amino silyl ether organocatalyst for the enantioselective diels-alder reaction of 1,2-dihydropyridines with aldehydes

Yuki Sakuta, Yoshihito Kohari, N. D.M.Romauli Hutabarat, Koji Uwai, Eunsang Kwon, Yuko Okuyama, Chigusa Seki, Haruo Matsuyama, Nobuhiro Takano, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The enantioselective Diels-Alder reactions of 1,2-dihydropyridines with acroleins using a chiral primary amino silyl ether organocatalyst afforded chiral isoquinuclidines with good chemical yields and excellent enantioselectivities (up to 70% and up to 99% ee).

Original languageEnglish
Pages (from-to)1379-1389
Number of pages11
JournalHeterocycles
Volume86
Issue number2
DOIs
Publication statusPublished - 2012

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