TY - JOUR
T1 - Chloride imbalance between serum and CSF in the acute phase of neuromyelitis optica
AU - Akaishi, Tetsuya
AU - Takahashi, Toshiyuki
AU - Nakashima, Ichiro
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/2/15
Y1 - 2018/2/15
N2 - We collected serum-cerebrospinal fluid (CSF)-paired samples during the acute phase of clinical episodes in MS and NMO patients, together with paired samples from non-MS/NMO patients, to compare the quotients of proteins and electrolytes among them. In NMO, the quotient of chloride was significantly higher in the acute phase of optic neuritis and brain lesions, but it was significantly lower in the acute phase of myelitis. Such findings were not observed in MS or in non-MS/NMO cases. With the coexistence of serum anti-AQP4-Ab, chloride imbalance between serum and CSF could be associated with the clinical episodes in NMO.
AB - We collected serum-cerebrospinal fluid (CSF)-paired samples during the acute phase of clinical episodes in MS and NMO patients, together with paired samples from non-MS/NMO patients, to compare the quotients of proteins and electrolytes among them. In NMO, the quotient of chloride was significantly higher in the acute phase of optic neuritis and brain lesions, but it was significantly lower in the acute phase of myelitis. Such findings were not observed in MS or in non-MS/NMO cases. With the coexistence of serum anti-AQP4-Ab, chloride imbalance between serum and CSF could be associated with the clinical episodes in NMO.
KW - Electrolyte imbalance
KW - Myelitis
KW - Neuromyelitis optica
KW - Optic neuritis
KW - Quotient of chloride
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U2 - 10.1016/j.jneuroim.2017.12.019
DO - 10.1016/j.jneuroim.2017.12.019
M3 - Article
C2 - 29306405
AN - SCOPUS:85039152999
SN - 0165-5728
VL - 315
SP - 45
EP - 49
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -