Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica

Tetsuya Akaishi; Toshiyuki Takahashi; Noriko Himori; Takayuki Takeshita; Toru Nakazawa; Masashi Aoki; Ichiro Nakashima

doi:10.1016/j.jneuroim.2018.03.010

Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica

Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Takayuki Takeshita, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (Q_Cl) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between Q_Cl and the length of ON-lesion. The visual prognosis also showed a positive correlation with Q_Cl in the acute phase (R = 0.58; p < 0.05). These results support the theory that chloride imbalance between serum and CSF may trigger the ON in NMO spectrum disorders.

Original language	English
Pages (from-to)	98-100
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	320
DOIs	https://doi.org/10.1016/j.jneuroim.2018.03.010
Publication status	Published - 2018 Jul 15

Keywords

Chloride imbalance
Neuromyelitis optica
Optic neuritis
Quotient of chloride
Visual prognosis

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10.1016/j.jneuroim.2018.03.010

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title = "Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica",

abstract = "Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (QCl) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between QCl and the length of ON-lesion. The visual prognosis also showed a positive correlation with QCl in the acute phase (R = 0.58; p < 0.05). These results support the theory that chloride imbalance between serum and CSF may trigger the ON in NMO spectrum disorders.",

keywords = "Chloride imbalance, Neuromyelitis optica, Optic neuritis, Quotient of chloride, Visual prognosis",

author = "Tetsuya Akaishi and Toshiyuki Takahashi and Noriko Himori and Takayuki Takeshita and Toru Nakazawa and Masashi Aoki and Ichiro Nakashima",

note = "Funding Information: Ichiro Nakashima – Received Funding for a Trip and Speaks from Biogen Japan, Mitsubishi Tanabe Pharma, Novartis Pharma, Takeda Pharmaceutical Company. Served as an editorial board member of Multiple Sclerosis International. Received grant support from LSI Medience Corporation. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

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doi = "10.1016/j.jneuroim.2018.03.010",

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AU - Akaishi, Tetsuya

AU - Takahashi, Toshiyuki

AU - Himori, Noriko

AU - Takeshita, Takayuki

AU - Nakazawa, Toru

AU - Aoki, Masashi

AU - Nakashima, Ichiro

N1 - Funding Information: Ichiro Nakashima – Received Funding for a Trip and Speaks from Biogen Japan, Mitsubishi Tanabe Pharma, Novartis Pharma, Takeda Pharmaceutical Company. Served as an editorial board member of Multiple Sclerosis International. Received grant support from LSI Medience Corporation. Publisher Copyright: © 2018 Elsevier B.V.

PY - 2018/7/15

Y1 - 2018/7/15

N2 - Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (QCl) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between QCl and the length of ON-lesion. The visual prognosis also showed a positive correlation with QCl in the acute phase (R = 0.58; p < 0.05). These results support the theory that chloride imbalance between serum and CSF may trigger the ON in NMO spectrum disorders.

AB - Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (QCl) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between QCl and the length of ON-lesion. The visual prognosis also showed a positive correlation with QCl in the acute phase (R = 0.58; p < 0.05). These results support the theory that chloride imbalance between serum and CSF may trigger the ON in NMO spectrum disorders.

KW - Chloride imbalance

KW - Neuromyelitis optica

KW - Optic neuritis

KW - Quotient of chloride

KW - Visual prognosis

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ER -

Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica

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Keywords

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