Chromium-catalyzed migratory arylmagnesiation of unactivated alkynes

Jianming Yan, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


We report here on a chromium-catalyzed addition reaction of an arylmagnesium bromide to an unactivated internal alkyne to afford an ortho-alkenylarylmagnesium bromide. This reaction likely proceeds via the insertion of an alkyne into an arylchromium species, alkenyl-to-aryl 1,4-chromium migration, and transmetalation between the resulting arylchromium species and the starting aryl Grignard reagent. The product of this reaction is amenable to a series of electrophilic trapping reactions.

Original languageEnglish
Pages (from-to)1972-1975
Number of pages4
JournalOrganic Chemistry Frontiers
Issue number10
Publication statusPublished - 2017 Oct


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