Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report

Kengo Fukuoka; Kazuaki Tokodai; Shigehito Miyagi; Wataru Nakanishi; Ryuichi Nishimura; Atsushi Fujio; Hirofumi Watanabe; Shinji Taniuchi; Takeshi Naitoh; Takanori Ishida; Michiaki Unno; Takashi Kamei

doi:10.1016/j.transproceed.2020.02.130

Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report

Kengo Fukuoka, Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Hirofumi Watanabe, Shinji Taniuchi, Takeshi Naitoh, Takanori Ishida, Michiaki Unno, Takashi Kamei

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.

Original language	English
Pages (from-to)	1937-1939
Number of pages	3
Journal	Transplantation Proceedings
Volume	52
Issue number	6
DOIs	https://doi.org/10.1016/j.transproceed.2020.02.130
Publication status	Published - 2020 Jul 1

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Fukuoka, K., Tokodai, K., Miyagi, S., Nakanishi, W., Nishimura, R., Fujio, A., Watanabe, H., Taniuchi, S., Naitoh, T., Ishida, T., Unno, M., & Kamei, T. (2020). Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report. Transplantation Proceedings, 52(6), 1937-1939. https://doi.org/10.1016/j.transproceed.2020.02.130

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title = "Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report",

abstract = "Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.",

author = "Kengo Fukuoka and Kazuaki Tokodai and Shigehito Miyagi and Wataru Nakanishi and Ryuichi Nishimura and Atsushi Fujio and Hirofumi Watanabe and Shinji Taniuchi and Takeshi Naitoh and Takanori Ishida and Michiaki Unno and Takashi Kamei",

note = "Funding Information: This study was supported by JSPS KAKENHI (grant No. JP17K16502 ). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

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doi = "10.1016/j.transproceed.2020.02.130",

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Fukuoka, K, Tokodai, K, Miyagi, S, Nakanishi, W, Nishimura, R, Fujio, A , Watanabe, H, Taniuchi, S, Naitoh, T, Ishida, T , Unno, M & Kamei, T 2020, 'Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report', Transplantation Proceedings, vol. 52, no. 6, pp. 1937-1939. https://doi.org/10.1016/j.transproceed.2020.02.130

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T1 - Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation

T2 - A Case Report

AU - Fukuoka, Kengo

AU - Tokodai, Kazuaki

AU - Miyagi, Shigehito

AU - Nakanishi, Wataru

AU - Nishimura, Ryuichi

AU - Fujio, Atsushi

AU - Watanabe, Hirofumi

AU - Taniuchi, Shinji

AU - Naitoh, Takeshi

AU - Ishida, Takanori

AU - Unno, Michiaki

AU - Kamei, Takashi

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.

AB - Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.

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Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report

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