Clinical and serological study of tsutsugamushi disease

Koichi Watanabe, Shigeru Kohno, Toshiaki Hayashi, Mitsuo Kaku, Yasumasa Dotsu, Yuuichi Inoue, Yasuharu Masuyama, Keizo Yamaguchi, Masaki Hirota, Kohei Hara, Seigo Yamamoto, Norihiko Kawabata, Tsuneo Tsutsumi, Naomi Ito, Masamoto Nakano, Kiyotaka Komori

Research output: Contribution to journalArticlepeer-review


We report thirteen cases of tsutsugamushi disease, which was endemic in Nagasaki Prefecture from October to December 1987. All patients showed fever, skin rash and eschar. All cases were diagnosed serologically by indirect-immunofluorescense technique and treated with minocycline. Rickettsia tsutsugamushi was isolated from five cases. In a survey of anti-Karp, Kato, Gilliam, and newly discovered serotype (Kawasaki, Kuroki) antibodies, seven patients showed the highest antibody titers against the Kuroki strain and six against the Kawasaki strain. These findings suggest the prevalence of two serotypes of R. tsutsugamushi in Nagasaki Prefecture. The in vitro activities of six antibiotics against three clinically isolated strains of R. tsutsugamushi were determined by a cell culture method. Tetracycline, minocycline, dimethylchlortetracycline, and leucomycin showed stronger activity than chloramphenicol against R. tsutsugamushi.

Original languageEnglish
Pages (from-to)954-961
Number of pages8
Issue number12
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology


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