Clinical and serological study of tsutsugamushi disease

Koichi Watanabe; Shigeru Kohno; Toshiaki Hayashi; Mitsuo Kaku; Yasumasa Dotsu; Yuuichi Inoue; Yasuharu Masuyama; Keizo Yamaguchi; Masaki Hirota; Kohei Hara; Seigo Yamamoto; Norihiko Kawabata; Tsuneo Tsutsumi; Naomi Ito; Masamoto Nakano; Kiyotaka Komori

doi:10.11250/chemotherapy1953.36.12_954

Clinical and serological study of tsutsugamushi disease

Koichi Watanabe, Shigeru Kohno, Toshiaki Hayashi, Mitsuo Kaku, Yasumasa Dotsu, Yuuichi Inoue, Yasuharu Masuyama, Keizo Yamaguchi, Masaki Hirota, Kohei Hara, Seigo Yamamoto, Norihiko Kawabata, Tsuneo Tsutsumi, Naomi Ito, Masamoto Nakano, Kiyotaka Komori

Research output: Contribution to journal › Article › peer-review

Abstract

We report thirteen cases of tsutsugamushi disease, which was endemic in Nagasaki Prefecture from October to December 1987. All patients showed fever, skin rash and eschar. All cases were diagnosed serologically by indirect-immunofluorescense technique and treated with minocycline. Rickettsia tsutsugamushi was isolated from five cases. In a survey of anti-Karp, Kato, Gilliam, and newly discovered serotype (Kawasaki, Kuroki) antibodies, seven patients showed the highest antibody titers against the Kuroki strain and six against the Kawasaki strain. These findings suggest the prevalence of two serotypes of R. tsutsugamushi in Nagasaki Prefecture. The in vitro activities of six antibiotics against three clinically isolated strains of R. tsutsugamushi were determined by a cell culture method. Tetracycline, minocycline, dimethylchlortetracycline, and leucomycin showed stronger activity than chloramphenicol against R. tsutsugamushi.

Original language	English
Pages (from-to)	954-961
Number of pages	8
Journal	Chemotherapy
Volume	36
Issue number	12
DOIs	https://doi.org/10.11250/chemotherapy1953.36.12_954
Publication status	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11250/chemotherapy1953.36.12_954

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title = "Clinical and serological study of tsutsugamushi disease",

abstract = "We report thirteen cases of tsutsugamushi disease, which was endemic in Nagasaki Prefecture from October to December 1987. All patients showed fever, skin rash and eschar. All cases were diagnosed serologically by indirect-immunofluorescense technique and treated with minocycline. Rickettsia tsutsugamushi was isolated from five cases. In a survey of anti-Karp, Kato, Gilliam, and newly discovered serotype (Kawasaki, Kuroki) antibodies, seven patients showed the highest antibody titers against the Kuroki strain and six against the Kawasaki strain. These findings suggest the prevalence of two serotypes of R. tsutsugamushi in Nagasaki Prefecture. The in vitro activities of six antibiotics against three clinically isolated strains of R. tsutsugamushi were determined by a cell culture method. Tetracycline, minocycline, dimethylchlortetracycline, and leucomycin showed stronger activity than chloramphenicol against R. tsutsugamushi.",

author = "Koichi Watanabe and Shigeru Kohno and Toshiaki Hayashi and Mitsuo Kaku and Yasumasa Dotsu and Yuuichi Inoue and Yasuharu Masuyama and Keizo Yamaguchi and Masaki Hirota and Kohei Hara and Seigo Yamamoto and Norihiko Kawabata and Tsuneo Tsutsumi and Naomi Ito and Masamoto Nakano and Kiyotaka Komori",

year = "1988",

doi = "10.11250/chemotherapy1953.36.12_954",

language = "English",

volume = "36",

pages = "954--961",

journal = "CHEMOTHERAPY",

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T1 - Clinical and serological study of tsutsugamushi disease

AU - Watanabe, Koichi

AU - Kohno, Shigeru

AU - Hayashi, Toshiaki

AU - Kaku, Mitsuo

AU - Dotsu, Yasumasa

AU - Inoue, Yuuichi

AU - Masuyama, Yasuharu

AU - Yamaguchi, Keizo

AU - Hirota, Masaki

AU - Hara, Kohei

AU - Yamamoto, Seigo

AU - Kawabata, Norihiko

AU - Tsutsumi, Tsuneo

AU - Ito, Naomi

AU - Nakano, Masamoto

AU - Komori, Kiyotaka

PY - 1988

Y1 - 1988

N2 - We report thirteen cases of tsutsugamushi disease, which was endemic in Nagasaki Prefecture from October to December 1987. All patients showed fever, skin rash and eschar. All cases were diagnosed serologically by indirect-immunofluorescense technique and treated with minocycline. Rickettsia tsutsugamushi was isolated from five cases. In a survey of anti-Karp, Kato, Gilliam, and newly discovered serotype (Kawasaki, Kuroki) antibodies, seven patients showed the highest antibody titers against the Kuroki strain and six against the Kawasaki strain. These findings suggest the prevalence of two serotypes of R. tsutsugamushi in Nagasaki Prefecture. The in vitro activities of six antibiotics against three clinically isolated strains of R. tsutsugamushi were determined by a cell culture method. Tetracycline, minocycline, dimethylchlortetracycline, and leucomycin showed stronger activity than chloramphenicol against R. tsutsugamushi.

AB - We report thirteen cases of tsutsugamushi disease, which was endemic in Nagasaki Prefecture from October to December 1987. All patients showed fever, skin rash and eschar. All cases were diagnosed serologically by indirect-immunofluorescense technique and treated with minocycline. Rickettsia tsutsugamushi was isolated from five cases. In a survey of anti-Karp, Kato, Gilliam, and newly discovered serotype (Kawasaki, Kuroki) antibodies, seven patients showed the highest antibody titers against the Kuroki strain and six against the Kawasaki strain. These findings suggest the prevalence of two serotypes of R. tsutsugamushi in Nagasaki Prefecture. The in vitro activities of six antibiotics against three clinically isolated strains of R. tsutsugamushi were determined by a cell culture method. Tetracycline, minocycline, dimethylchlortetracycline, and leucomycin showed stronger activity than chloramphenicol against R. tsutsugamushi.

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Clinical and serological study of tsutsugamushi disease

Abstract

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