Clinical application of18F-FUdR in glioma patients - PET study of nucleic acid metabolism

Motonobu Kameyama; Kiichi Ishiwata; Yuji Tsurumi; Jun Itoh; Kiyotaka Sato; Ryuichi Katakura; Takashi Yoshimoto; Jun Hatazawa; Masatoshi Ito; Tatsuo Ido

doi:10.1007/BF01058459

Clinical application of¹⁸F-FUdR in glioma patients - PET study of nucleic acid metabolism

Motonobu Kameyama, Kiichi Ishiwata, Yuji Tsurumi, Jun Itoh, Kiyotaka Sato, Ryuichi Katakura, Takashi Yoshimoto, Jun Hatazawa, Masatoshi Ito, Tatsuo Ido

Cyclotron and Radioisotope Center (CYRIC)

Tohoku University

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Positron emission tomography was used to investigate the metabolism of nucleic acids by¹⁸F-fluoro-2′-deoxyuridine (¹⁸F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-¹⁸F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.

Original language	English
Pages (from-to)	53-61
Number of pages	9
Journal	Journal of Neuro-Oncology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/BF01058459
Publication status	Published - 1995 Feb

Keywords

F-fluoro-2′-deoxyuridine
brain tumor
glioma
nucleic acid metabolism
PET

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF01058459

Cite this

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abstract = "Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2′-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.",

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T1 - Clinical application of18F-FUdR in glioma patients - PET study of nucleic acid metabolism

AU - Kameyama, Motonobu

AU - Ishiwata, Kiichi

AU - Tsurumi, Yuji

AU - Itoh, Jun

AU - Sato, Kiyotaka

AU - Katakura, Ryuichi

AU - Yoshimoto, Takashi

AU - Hatazawa, Jun

AU - Ito, Masatoshi

AU - Ido, Tatsuo

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AB - Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2′-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.

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