Clinical correlations between treatment with anticoagulants/antiaggregants and late rectal toxicity after radiotherapy for prostate cancer

Ken Takeda; Yoshihiro Ogawa; Hisanori Ariga; Masashi Koto; Toru Sakayauchi; Keisuke Fujimoto; Kakutaro Narazaki; Masatoshi Mitsuya; Yoshihiro Takai; Shogo Yamada

Clinical correlations between treatment with anticoagulants/antiaggregants and late rectal toxicity after radiotherapy for prostate cancer

Ken Takeda, Yoshihiro Ogawa, Hisanori Ariga, Masashi Koto, Toru Sakayauchi, Keisuke Fujimoto, Kakutaro Narazaki, Masatoshi Mitsuya, Yoshihiro Takai, Shogo Yamada

MED - Health Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformai radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6%. On multivariate analysis, medication with anticoagulants/ antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.

Original language	English
Pages (from-to)	1831-1834
Number of pages	4
Journal	Anticancer Research
Volume	29
Issue number	5
Publication status	Published - 2009 May

Keywords

Late toxicity
Prostate cancer
Radiotherapy
Rectal toxicity

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Clinical correlations between treatment with anticoagulants/antiaggregants and late rectal toxicity after radiotherapy for prostate cancer",

abstract = "Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformai radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6%. On multivariate analysis, medication with anticoagulants/ antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.",

keywords = "Late toxicity, Prostate cancer, Radiotherapy, Rectal toxicity",

author = "Ken Takeda and Yoshihiro Ogawa and Hisanori Ariga and Masashi Koto and Toru Sakayauchi and Keisuke Fujimoto and Kakutaro Narazaki and Masatoshi Mitsuya and Yoshihiro Takai and Shogo Yamada",

year = "2009",

month = may,

language = "English",

volume = "29",

pages = "1831--1834",

journal = "Anticancer Research",

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TY - JOUR

T1 - Clinical correlations between treatment with anticoagulants/antiaggregants and late rectal toxicity after radiotherapy for prostate cancer

AU - Takeda, Ken

AU - Ogawa, Yoshihiro

AU - Ariga, Hisanori

AU - Koto, Masashi

AU - Sakayauchi, Toru

AU - Fujimoto, Keisuke

AU - Narazaki, Kakutaro

AU - Mitsuya, Masatoshi

AU - Takai, Yoshihiro

AU - Yamada, Shogo

PY - 2009/5

Y1 - 2009/5

N2 - Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformai radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6%. On multivariate analysis, medication with anticoagulants/ antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.

AB - Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformai radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6%. On multivariate analysis, medication with anticoagulants/ antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.

KW - Late toxicity

KW - Prostate cancer

KW - Radiotherapy

KW - Rectal toxicity

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Clinical correlations between treatment with anticoagulants/antiaggregants and late rectal toxicity after radiotherapy for prostate cancer

Abstract

Keywords

UN SDGs

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