Clinical courses and pregnancy outcomes in Japanese women with inflammatory bowel disease

Katsuya Endo; Seiichi Takahashi; Yosuke Shimodaira; Hitoshi Nagasawa; Rintaro Moroi; Masatake Kuroha; Takashi Arai; Yoshitake Kanazawa; Hisashi Shiga; Yoichi Kakuta; Yoshitaka Kinouchi; Tooru Shimosegawa

Clinical courses and pregnancy outcomes in Japanese women with inflammatory bowel disease

Katsuya Endo, Seiichi Takahashi, Yosuke Shimodaira, Hitoshi Nagasawa, Rintaro Moroi, Masatake Kuroha, Takashi Arai, Yoshitake Kanazawa, Hisashi Shiga, Yoichi Kakuta, Yoshitaka Kinouchi, Tooru Shimosegawa

Tohoku University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In this study, we analyzed the clinical courses and the pregnancy outcomes in Japanese women with inflammatory bowel disease (IBD) in our hospital in the recent 10 years. We analyzed 49 pregnancies in 38 patients with ulcerative colitis (UC) and 24 pregnancies in 16 patients with Crohn's disease (CD) retrospectively. The results indicated that pregnancy has less influence on the clinical courses of IBD and that IBD also has less influence on the pregnancy outcomes. However, we should pay attention to the results that the patients with CD tend to deteriorate if conception occurs when CD is active and that patients with active UC tend to have more adverse pregnancy outcomes than patients in remission. In conclusion, patients with IBD are recommended to become pregnant when the diseases are in remission and treatment using selected safe medications should be continued during the pregnancy.

Original language	English
Pages (from-to)	1858-1871
Number of pages	14
Journal	Japanese Journal of Gastroenterology
Volume	108
Issue number	11
Publication status	Published - 2011 Nov

Cite this

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abstract = "In this study, we analyzed the clinical courses and the pregnancy outcomes in Japanese women with inflammatory bowel disease (IBD) in our hospital in the recent 10 years. We analyzed 49 pregnancies in 38 patients with ulcerative colitis (UC) and 24 pregnancies in 16 patients with Crohn's disease (CD) retrospectively. The results indicated that pregnancy has less influence on the clinical courses of IBD and that IBD also has less influence on the pregnancy outcomes. However, we should pay attention to the results that the patients with CD tend to deteriorate if conception occurs when CD is active and that patients with active UC tend to have more adverse pregnancy outcomes than patients in remission. In conclusion, patients with IBD are recommended to become pregnant when the diseases are in remission and treatment using selected safe medications should be continued during the pregnancy.",

author = "Katsuya Endo and Seiichi Takahashi and Yosuke Shimodaira and Hitoshi Nagasawa and Rintaro Moroi and Masatake Kuroha and Takashi Arai and Yoshitake Kanazawa and Hisashi Shiga and Yoichi Kakuta and Yoshitaka Kinouchi and Tooru Shimosegawa",

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AU - Endo, Katsuya

AU - Takahashi, Seiichi

AU - Shimodaira, Yosuke

AU - Nagasawa, Hitoshi

AU - Moroi, Rintaro

AU - Kuroha, Masatake

AU - Arai, Takashi

AU - Kanazawa, Yoshitake

AU - Shiga, Hisashi

AU - Kakuta, Yoichi

AU - Kinouchi, Yoshitaka

AU - Shimosegawa, Tooru

PY - 2011/11

Y1 - 2011/11

N2 - In this study, we analyzed the clinical courses and the pregnancy outcomes in Japanese women with inflammatory bowel disease (IBD) in our hospital in the recent 10 years. We analyzed 49 pregnancies in 38 patients with ulcerative colitis (UC) and 24 pregnancies in 16 patients with Crohn's disease (CD) retrospectively. The results indicated that pregnancy has less influence on the clinical courses of IBD and that IBD also has less influence on the pregnancy outcomes. However, we should pay attention to the results that the patients with CD tend to deteriorate if conception occurs when CD is active and that patients with active UC tend to have more adverse pregnancy outcomes than patients in remission. In conclusion, patients with IBD are recommended to become pregnant when the diseases are in remission and treatment using selected safe medications should be continued during the pregnancy.

AB - In this study, we analyzed the clinical courses and the pregnancy outcomes in Japanese women with inflammatory bowel disease (IBD) in our hospital in the recent 10 years. We analyzed 49 pregnancies in 38 patients with ulcerative colitis (UC) and 24 pregnancies in 16 patients with Crohn's disease (CD) retrospectively. The results indicated that pregnancy has less influence on the clinical courses of IBD and that IBD also has less influence on the pregnancy outcomes. However, we should pay attention to the results that the patients with CD tend to deteriorate if conception occurs when CD is active and that patients with active UC tend to have more adverse pregnancy outcomes than patients in remission. In conclusion, patients with IBD are recommended to become pregnant when the diseases are in remission and treatment using selected safe medications should be continued during the pregnancy.

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Clinical courses and pregnancy outcomes in Japanese women with inflammatory bowel disease

Abstract

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