Purpose: This study aimed to prospectively evaluate the clinical performance of monolithic zirconia crowns made of yttria-stabilized tetragonal zirconia polycrystal. Materials and Methods: A total of 26 crowns placed on premolar or molar teeth in 18 patients were evaluated at the time of crown placement and at 2 weeks, 6 months, 1 year, and 2 years after placement. Results: Twenty-five crowns rated as satisfactory according to the California Dental Association quality evaluation system. Most of the abutment and antagonist teeth showed good periodontal condition. An enamel cracking occurred on one antagonist tooth 1 year after placement. Conclusion: Monolithic zirconia crowns can be a clinically acceptable prosthetic option.