Clinicopathologic Evaluation of 49 Patients of Cystic Diseases of the Liver

Heigo Takeuchi, Masanori Suzuki, Fukuhara Kenji, Michiaki Unno, Koujin Endou, Youichi Narushima, Toshiki Rikiyama, Nobuhide Sakamoto, Masao Shinoda, Seiki Matsuno

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Forty-nine patients with cystic disease of the liver were reviewed. Three simple liver cysts were diagnosed as cystadenocarcinoma of the liver based on the findings of X-ray-CT or ultrasonography. One cystadenocarcinoma of the liver seemed to be a simple cyst before being diagnosed by histological examination. The levels of CA19-9 and CEA in the cystic fluid of benign liver cysts were much higher than the upper normal limit for serum but within normal limits in the corresponding serum. Examination of cystic fluid of the liver does not appear to be an aid in the diagnosis since the levels of the tumor markers were high not only in malignancy but in benign diseases. In epithelial cells of the wall of benign liver cysts, there was positive immunohistochemical staining for CEA in a non-polar pattern. It seems that immunohistochemical examination is an useful means to predict the outcome of cysts and cystadenomas of the liver.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalJapanese Journal of Gastroenterological Surgery
Issue number3
Publication statusPublished - 1997


  • Carcinoembryonic antigen
  • Cystadenocarcinoma of the liver
  • Cystadenoma of the liver
  • Immunohistochemistry
  • Liver cyst


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