TY - JOUR
T1 - Clinicopathologic features, treatment, prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium
T2 - A retrospective analysis of 42 cases from the Kansai clinical oncology group/intergroup study in Japan
AU - Matsumoto, Harunobu
AU - Shimokawa, Mototsugu
AU - Nasu, Kaei
AU - Shikama, Ayumi
AU - Shiozaki, Takaya
AU - Futagami, Masayuki
AU - Kai, Kentaro
AU - Nagano, Hiroaki
AU - Mori, Taisuke
AU - Yano, Mitsutake
AU - Sugino, Norihiro
AU - Fujimoto, Etsuko
AU - Yoshioka, Norihito
AU - Nakagawa, Satoshi
AU - Shimada, Muneaki
AU - Tokunaga, Hideki
AU - Yamada, Yuki
AU - Tsuruta, Tomohiko
AU - Tasaki, Kazuto
AU - Nishikawa, Ryutaro
AU - Kuji, Shiho
AU - Motohashi, Takashi
AU - Ito, Kimihiko
AU - Yamada, Takashi
AU - Teramoto, Norihiro
N1 - Publisher Copyright:
© 2019. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.
PY - 2019/11
Y1 - 2019/11
N2 - Objective: We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease. Methods: At medical institutions participating in the Kansai Clinical Oncology Group/ Intergroup, cases diagnosed at a central pathologic review as neuroendocrine carcinoma of the endometrium between 1995 and 2014 were enrolled. We retrospectively analyzed the clinicopathologic features, treatment, prognosis and prognostic factors of this disease. Results: A total of 65 cases were registered from 18 medical institutions in Japan. Of these, 42 (64.6%) cases were diagnosed as neuroendocrine carcinoma of the endometrium based on the central pathological review and thus included in the study. Advanced International Federation of Gynecology and Obstetrics stages (stage III and IV) and pure type small cell neuroendocrine carcinoma cases had a significantly worse prognosis. Upon multivariate analysis, only histologic subtypes and surgery were significant prognostic factors. Pure type cases had a significantly worse prognosis compared to mixed type cases and complete surgery cases had a significantly better prognosis compared to cases with no or incomplete surgery. Conclusion: Our findings suggest that complete surgery improves the prognosis of neuroendocrine carcinoma of the endometrium. Even among cases with advanced disease stages, if complete surgery is expected to be achieved, clinicians should consider curative surgery to improve the prognosis of neuroendocrine carcinoma of the endometrium.
AB - Objective: We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease. Methods: At medical institutions participating in the Kansai Clinical Oncology Group/ Intergroup, cases diagnosed at a central pathologic review as neuroendocrine carcinoma of the endometrium between 1995 and 2014 were enrolled. We retrospectively analyzed the clinicopathologic features, treatment, prognosis and prognostic factors of this disease. Results: A total of 65 cases were registered from 18 medical institutions in Japan. Of these, 42 (64.6%) cases were diagnosed as neuroendocrine carcinoma of the endometrium based on the central pathological review and thus included in the study. Advanced International Federation of Gynecology and Obstetrics stages (stage III and IV) and pure type small cell neuroendocrine carcinoma cases had a significantly worse prognosis. Upon multivariate analysis, only histologic subtypes and surgery were significant prognostic factors. Pure type cases had a significantly worse prognosis compared to mixed type cases and complete surgery cases had a significantly better prognosis compared to cases with no or incomplete surgery. Conclusion: Our findings suggest that complete surgery improves the prognosis of neuroendocrine carcinoma of the endometrium. Even among cases with advanced disease stages, if complete surgery is expected to be achieved, clinicians should consider curative surgery to improve the prognosis of neuroendocrine carcinoma of the endometrium.
KW - Endometrial Neoplasms
KW - Large Cell Carcinoma
KW - Neuroendocrine Carcinoma
KW - Prognosis
KW - Small Cell Carcinoma
KW - Surgery
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U2 - 10.3802/jgo.2019.30.e103
DO - 10.3802/jgo.2019.30.e103
M3 - Article
C2 - 31576694
AN - SCOPUS:85072847653
SN - 2005-0380
VL - 30
JO - Journal of Gynecologic Oncology
JF - Journal of Gynecologic Oncology
IS - 6
M1 - e103
ER -