TY - JOUR
T1 - Cloning of the γ chain of the human IL-2 receptor
AU - Takeshita, Toshikazu
AU - Asao, Hironobu
AU - Ohtani, Kiyoshi
AU - Ishii, Naoto
AU - Kumaki, Satoru
AU - Tanaka, Nobuyuki
AU - Munakata, Hiroshi
AU - Nakamura, Masataka
AU - Sugamura, Kazuo
PY - 1992
Y1 - 1992
N2 - A third subunit, the γ chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The γ chain is necessary for the formation of the high- and intermediate-affinity receptors, which consist of αβγ heterotrimers and βγ heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the γ chain is present; α and β are insufficient for internalization. Thus, the γ chain is an indispensable component of the functional IL-2R.
AB - A third subunit, the γ chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The γ chain is necessary for the formation of the high- and intermediate-affinity receptors, which consist of αβγ heterotrimers and βγ heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the γ chain is present; α and β are insufficient for internalization. Thus, the γ chain is an indispensable component of the functional IL-2R.
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U2 - 10.1126/science.1631559
DO - 10.1126/science.1631559
M3 - Article
C2 - 1631559
AN - SCOPUS:0026684134
SN - 0036-8075
VL - 257
SP - 379
EP - 382
JO - Science
JF - Science
IS - 5068
ER -