TY - JOUR
T1 - Close linkage of human chromosomal pepsinogen A genes
AU - Hayano, Toshiya
AU - Sogawa, Kazuhiro
AU - Ichihara, Yoshikazu
AU - Fujii-Kuriyama, Yoshiaki
AU - Takahashi, Kenji
PY - 1986/7/16
Y1 - 1986/7/16
N2 - We have obtained a clone containing two pepsinogen A genes in a single insert by screening a recombinant cosmid library for human genomic DNA. Restriction endonuclease mappings of this cloned DNA showed that these two genes are very similar, but distinct in structure, and that they are closely linked to one another in the human chromosome DNA. The close arrangement of the genes with very similar structures could facilitate the homologous recombination or the unequal crossing-over which accounts for high frequency of haplotype variation in copy number of pepsinogen A genes as reported by Taggart et al.
AB - We have obtained a clone containing two pepsinogen A genes in a single insert by screening a recombinant cosmid library for human genomic DNA. Restriction endonuclease mappings of this cloned DNA showed that these two genes are very similar, but distinct in structure, and that they are closely linked to one another in the human chromosome DNA. The close arrangement of the genes with very similar structures could facilitate the homologous recombination or the unequal crossing-over which accounts for high frequency of haplotype variation in copy number of pepsinogen A genes as reported by Taggart et al.
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U2 - 10.1016/0006-291X(86)90278-0
DO - 10.1016/0006-291X(86)90278-0
M3 - Article
C2 - 3017318
AN - SCOPUS:0022525129
SN - 0006-291X
VL - 138
SP - 289
EP - 296
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -