Close linkage of MEN2A with RBP3 locus in Japanese kindreds

Masayuki Yamamoto; Shin ichiro Takai; Tetsuro Miki; Kazuyoshi Motomura; Makoto Okazaki; Isamu Nishisho; Hideo Tateishi; Akira Miyauchi; Tasuku Honjo; A. J. Pakstis; Takesada Mori

doi:10.1007/BF00291173

Close linkage of MEN2A with RBP3 locus in Japanese kindreds

Masayuki Yamamoto, Shin ichiro Takai, Tetsuro Miki, Kazuyoshi Motomura, Makoto Okazaki, Isamu Nishisho, Hideo Tateishi, Akira Miyauchi, Tasuku Honjo, A. J. Pakstis, Takesada Mori

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromsome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.

Original language	English
Pages (from-to)	287-288
Number of pages	2
Journal	Human Genetics
Volume	82
Issue number	3
DOIs	https://doi.org/10.1007/BF00291173
Publication status	Published - 1989 Jun
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1007/BF00291173

Cite this

@article{93c4a957e15e47259d263c081fff6ecf,

title = "Close linkage of MEN2A with RBP3 locus in Japanese kindreds",

abstract = "The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromsome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.",

author = "Masayuki Yamamoto and Takai, {Shin ichiro} and Tetsuro Miki and Kazuyoshi Motomura and Makoto Okazaki and Isamu Nishisho and Hideo Tateishi and Akira Miyauchi and Tasuku Honjo and Pakstis, {A. J.} and Takesada Mori",

year = "1989",

month = jun,

doi = "10.1007/BF00291173",

language = "English",

volume = "82",

pages = "287--288",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - Close linkage of MEN2A with RBP3 locus in Japanese kindreds

AU - Yamamoto, Masayuki

AU - Takai, Shin ichiro

AU - Miki, Tetsuro

AU - Motomura, Kazuyoshi

AU - Okazaki, Makoto

AU - Nishisho, Isamu

AU - Tateishi, Hideo

AU - Miyauchi, Akira

AU - Honjo, Tasuku

AU - Pakstis, A. J.

AU - Mori, Takesada

PY - 1989/6

Y1 - 1989/6

N2 - The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromsome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.

AB - The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromsome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.

UR - http://www.scopus.com/inward/record.url?scp=0024380425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024380425&partnerID=8YFLogxK

U2 - 10.1007/BF00291173

DO - 10.1007/BF00291173

M3 - Article

C2 - 2567278

AN - SCOPUS:0024380425

SN - 0340-6717

VL - 82

SP - 287

EP - 288

JO - Human Genetics

JF - Human Genetics

IS - 3

ER -

Close linkage of MEN2A with RBP3 locus in Japanese kindreds

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this