Close linkage of MEN2A with RBP3 locus in Japanese kindreds

Masayuki Yamamoto, Shin ichiro Takai, Tetsuro Miki, Kazuyoshi Motomura, Makoto Okazaki, Isamu Nishisho, Hideo Tateishi, Akira Miyauchi, Tasuku Honjo, A. J. Pakstis, Takesada Mori

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromsome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.

Original languageEnglish
Pages (from-to)287-288
Number of pages2
JournalHuman Genetics
Issue number3
Publication statusPublished - 1989 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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