Coating bone-like apatite onto organic substrates using solutions mimicking body fluid

Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Bone-like apatite is a carbonated hydroxyapatite with a small crystallite and low crystallinity. The formation of a layer consisting of bone-like apatite is an essential condition for bioactive materials to achieve direct bonding with living bone. A bone-like apatite layer can be formed on the surface of organic substrates in a solution mimicking a body fluid when some functional groups are introduced to organic substrates. This process is a biomimetic process because a simulated body fluid and related solutions are used to deposit bone-like apatite crystals and promote crystal growth. Coating of bone-like apatite layers through biomimetic processes has received much attention in the fabrication of novel composites with bone-bonding properties, i.e. bioactivity, and mechanical properties analogous to those of living bone tissues. This paper reviews recent developments in coating with bone-like apatite layers using biomimetic processes.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number1
Publication statusPublished - 2007


  • Biomimetic process
  • Bone
  • Bone-like apatite
  • Coating
  • Composite
  • Simulated body fluid


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