Coating stability and blood compatibility of stainless steel surface modified with phospholipid polymer

Nobuyuki Morimoto, Ikue Sato, Akihiko Watanabe, Nobuo Nakabayashi, Yasuhiko Iwasaki, Kazuhiko Ishihara

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


To improve the blood compatibility of the surface of stainless steel, which is used as a base material of stent for cardiovascular treatment, the surface was coated with a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. 4-Methacryloyloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA) polymer was precoated on the stainless steel plate as a binder to obtain the long term stability of the MPC polymer. The surface of modified stainless steel was analyzed with XPS. The amount of the polymer eluted from the surfaces was evaluated by soaking samples in water for 14 days at 37°C. All of MPC polymer directly coated on stainless plate was eluted after 14 days soaking. On the other hand, the elution of the MPC polymer was significantly reduced by precoating of 4-META/MMA polymer on stainless plate. This surface effectively reduced protein adsorption and platelet adhesion. MPC polymer coated with 4-META/MMA polymer on stainless steel will be a useful technique as surface modification of the stent.

Original languageEnglish
Pages (from-to)432-437
Number of pages6
Issue number7
Publication statusPublished - 2002
Externally publishedYes


  • 2-Methacryloyloxyethyl phosphorylcholine polymer
  • 4-Methacryloyloxyethyl trimellitate anhydride
  • Blood compatibility
  • Coating stability
  • Methyl methacrylate polymer
  • Stainless steel

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics


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