Cobalt-catalyzed alkenylation of thiazoles with alkynes via C-H bond functionalization

Zhenhua Ding; Naohiko Yoshikai

doi:10.1055/s-0030-1260077

Cobalt-catalyzed alkenylation of thiazoles with alkynes via C-H bond functionalization

Zhenhua Ding, Naohiko Yoshikai

PHA - Molecular Pharmaceutical Science

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A cobalt-Xantphos catalyst has been developed for the syn addition of (benzo)thiazoles to internal alkynes via C-H bond functionalization. The reaction affords C2-alkenylated (benzo)thiazoles with high regio- and stereoselectivities under mild conditions.

Original language	English
Article number	C29411SS
Pages (from-to)	2561-2566
Number of pages	6
Journal	Synthesis
Issue number	16
DOIs	https://doi.org/10.1055/s-0030-1260077
Publication status	Published - 2011

Keywords

alkynes
C-H activation
cobalt
heterocycles
hydroarylation

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10.1055/s-0030-1260077

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title = "Cobalt-catalyzed alkenylation of thiazoles with alkynes via C-H bond functionalization",

abstract = "A cobalt-Xantphos catalyst has been developed for the syn addition of (benzo)thiazoles to internal alkynes via C-H bond functionalization. The reaction affords C2-alkenylated (benzo)thiazoles with high regio- and stereoselectivities under mild conditions.",

keywords = "alkynes, C-H activation, cobalt, heterocycles, hydroarylation",

author = "Zhenhua Ding and Naohiko Yoshikai",

year = "2011",

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T1 - Cobalt-catalyzed alkenylation of thiazoles with alkynes via C-H bond functionalization

AU - Ding, Zhenhua

AU - Yoshikai, Naohiko

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N2 - A cobalt-Xantphos catalyst has been developed for the syn addition of (benzo)thiazoles to internal alkynes via C-H bond functionalization. The reaction affords C2-alkenylated (benzo)thiazoles with high regio- and stereoselectivities under mild conditions.

AB - A cobalt-Xantphos catalyst has been developed for the syn addition of (benzo)thiazoles to internal alkynes via C-H bond functionalization. The reaction affords C2-alkenylated (benzo)thiazoles with high regio- and stereoselectivities under mild conditions.

KW - alkynes

KW - C-H activation

KW - cobalt

KW - heterocycles

KW - hydroarylation

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JF - Synthesis

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M1 - C29411SS

ER -

Cobalt-catalyzed alkenylation of thiazoles with alkynes via C-H bond functionalization

Abstract

Keywords

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