Cobalt-Catalyzed Alkenylzincation of Unfunctionalized Alkynes

Junliang Wu, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


While transition metal catalyzed addition reactions of arylmetal reagents to unfunctionalized alkynes have been extensively developed in the last decade, analogous reactions using alkenylmetal reagents remain rare regardless of their potential utility for the synthesis of unsymmetrical 1,3-dienes. Reported herein is the development of a cobalt/diphosphine catalyst which promotes efficient and stereoselective addition of alkenylzinc reagents to unfunctionalized internal alkynes. The resulting dienylzinc species serve as versatile intermediates for further synthetic transformations.

Original languageEnglish
Pages (from-to)336-340
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number1
Publication statusPublished - 2016 Jan 4


  • alkenes
  • alkynes
  • cobalt
  • homogeneous catalysis
  • organometallic reagents


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