Cobalt-catalyzed directed: Ortho -methylation of arenes with methyl tosylate

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A cobalt-catalyzed directed ortho C-H methylation reaction of arenes has been achieved using readily available methyl tosylate as a methylating agent. An in situ-generated cobalt-N-heterocyclic carbene catalyst in combination with neopentylmagnesium bromide promotes the methylation at room temperature. The reaction is applicable to various substrates bearing nitrogen directing groups such as N-aryl imine, N-H imine, and 2-pyridyl groups. The present protocol also allows for facile introduction of a trideuteriomethyl group into arenes.

Original languageEnglish
Pages (from-to)2214-2218
Number of pages5
JournalOrganic Chemistry Frontiers
Issue number14
Publication statusPublished - 2018 Jul 21


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