Cobalt-Catalyzed Enantioselective Directed C-H Alkylation of Indole with Styrenes

Pin Sheng Lee, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)


A cobalt-chiral phosphoramidite catalyst promotes enantioselective imine-directed C2-alkylation of Boc-protected indoles with styrenes. The reaction affords 1,1-diarylethane products in moderate to good yields with good enantioselectivities under mild conditions. A deuterium-labeling experiment suggests that the enantioselectivity is controlled by both the styrene insertion and the C-C reductive elimination steps. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalOrganic letters
Issue number1
Publication statusPublished - 2015 Jan 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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