A cobalt-chiral phosphoramidite catalyst promotes enantioselective imine-directed C2-alkylation of Boc-protected indoles with styrenes. The reaction affords 1,1-diarylethane products in moderate to good yields with good enantioselectivities under mild conditions. A deuterium-labeling experiment suggests that the enantioselectivity is controlled by both the styrene insertion and the C-C reductive elimination steps. (Chemical Equation Presented).
|Number of pages||4|
|Publication status||Published - 2015 Jan 2|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry