Cobalt-catalyzed enantioselective intramolecular hydroacylation of ketones and olefins

Junfeng Yang, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

162 Citations (Scopus)


Cobalt-chiral diphoshine catalytic systems promote intramolecular hydroacylation reactions of 2-acylbenzaldehydes and 2-alkenylbenzaldehydes to afford phthalide and indanone derivatives, respectively, in moderate to good yields with high enantioselectivities. The ketone hydroacylation did not exhibit a significant H/D kinetic isotope effect (KIE) with respect to the aldehyde C-H bond, indicating that C-H activation would not be involved in the rate-limiting step.

Original languageEnglish
Pages (from-to)16748-16751
Number of pages4
JournalJournal of the American Chemical Society
Issue number48
Publication statusPublished - 2014 Dec 3


Dive into the research topics of 'Cobalt-catalyzed enantioselective intramolecular hydroacylation of ketones and olefins'. Together they form a unique fingerprint.

Cite this