A simple cobalt-diphosphine catalyst has been found to efficiently promote intramolecular cyclization of ortho-cyclopropylvinyl- and cyclopropylidenemethyl-substituted benzaldehydes into benzocyclooctadienone and benzocycloheptadienone derivatives, respectively. This ring-opening hydroacylation likely involves aldehyde C−H oxidative addition, olefin insertion, cyclopropane cleavage by β-carbon elimination, and C−C bond-forming reductive elimination, as was supported by mechanistic experiments and DFT calculations.
|Number of pages||6|
|Journal||Chemistry - A European Journal|
|Publication status||Published - 2020 Jul 2|
- C−C bond cleavage
- C−H activation
ASJC Scopus subject areas
- Organic Chemistry