Cobalt-catalyzed intramolecular olefin hydroarylation leading to dihydropyrroloindoles and tetrahydropyridoindoles

Zhenhua Ding; Naohiko Yoshikai

doi:10.1002/anie.201305151

Cobalt-catalyzed intramolecular olefin hydroarylation leading to dihydropyrroloindoles and tetrahydropyridoindoles

Zhenhua Ding, Naohiko Yoshikai

PHA - Molecular Pharmaceutical Science

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand.

Original language	English
Pages (from-to)	8574-8578
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	33
DOIs	https://doi.org/10.1002/anie.201305151
Publication status	Published - 2013 Aug 12

Keywords

C-H activation
alkenes
cobalt
indoles
intramolecular reactions

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abstract = "Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand.",

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author = "Zhenhua Ding and Naohiko Yoshikai",

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AU - Ding, Zhenhua

AU - Yoshikai, Naohiko

PY - 2013/8/12

Y1 - 2013/8/12

N2 - Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand.

AB - Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand.

KW - C-H activation

KW - alkenes

KW - cobalt

KW - indoles

KW - intramolecular reactions

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Cobalt-catalyzed intramolecular olefin hydroarylation leading to dihydropyrroloindoles and tetrahydropyridoindoles

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Keywords

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