Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines

Ke Gao, Rupankar Paira, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


A cobalt-N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C-H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions.

Original languageEnglish
Pages (from-to)1486-1490
Number of pages5
JournalAdvanced Synthesis and Catalysis
Issue number7
Publication statusPublished - 2014 May 5


  • aziridines
  • C-C bond formation
  • C-H functionalization
  • cobalt


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