Collagen characterization by polarized and acoustic microscopy

Y. Saijo, H. Sasaki, S. Nitta, M. Tanaka, C. S. Jorgensen, E. Falk

Research output: Contribution to journalConference articlepeer-review


Rupture of the fibrous cap overlying a soft lipid pool in atherosclerotic plaque is the trigger for acute coronary syndrome. As collagen is the main component of the fibrous cap, determination of its mechanical properties is important. In this regard, the feasibility of scanning acoustic microscopy and polarized microscopy was studied using treated aortic root samples from Apo-E deficient and normal mice. Very high frequency ultrasound of the SAM could provide information of collagen type without staining, while lower frequency intravascular ultrasound offer some possibilities. As ultrasound features correlate closely with the material mechanical properties, the imaging modality may be used to evaluate the stability of atherosclerotic plaques.

Original languageEnglish
Pages (from-to)A57
JournalUltrasound in Medicine and Biology
Issue numberSUPPL. 2
Publication statusPublished - 2000
EventThe 9th Congress of World Federation for Ultrasound in Medicine and Biology - Florence, Italy
Duration: 2000 May 62000 May 10


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