TY - JOUR
T1 - Colon-targeted delivery of liver hydrolysates
T2 - Efficacy in reversing carbon tetrachloride-induced liver damage
AU - Li, Li
AU - Chen, Jianfa
AU - Li, Yanping
AU - Lv, Yingnian
AU - Wu, Kefeng
AU - Liu, Yi
AU - Cui, Liao
N1 - Funding Information:
This study was supported by a Science Grant from DongGuan Higher Educational Institute and Healthcare Organization (Grant No. 2008108101059).
PY - 2013
Y1 - 2013
N2 - Liver hydrolysates contain various active polypeptides with multiple physiological functions. Oral colon-targeted drug delivery is a potential delivery approach for proteins and therapeutic polypeptides. The aim of this study was to assess the enhancement of the protective effect of liver hydrolysates on liver injury by using a colon-targeted delivery system. Rats were orally administered with a colon-targeted capsule with or without swine liver hydrolysates (22.5 or 5.625 mg/kg) or given the same daily doses of liver hydrolysates via the regular gavage route for 30 days, followed by induction of liver injury with carbon tetrachloride (CCl4). Pathological analysis showed that liver hydrolysates delivered via the colon-targeted capsules had a significant improving protective effect on CCl4-induced damage to the rats' liver when compared to liver hydrolysates administered intragastrically by gavage. This study supports the feasibility of oral colon-targeted drug delivery for proteins, therapeutic polypeptides, and functional food.
AB - Liver hydrolysates contain various active polypeptides with multiple physiological functions. Oral colon-targeted drug delivery is a potential delivery approach for proteins and therapeutic polypeptides. The aim of this study was to assess the enhancement of the protective effect of liver hydrolysates on liver injury by using a colon-targeted delivery system. Rats were orally administered with a colon-targeted capsule with or without swine liver hydrolysates (22.5 or 5.625 mg/kg) or given the same daily doses of liver hydrolysates via the regular gavage route for 30 days, followed by induction of liver injury with carbon tetrachloride (CCl4). Pathological analysis showed that liver hydrolysates delivered via the colon-targeted capsules had a significant improving protective effect on CCl4-induced damage to the rats' liver when compared to liver hydrolysates administered intragastrically by gavage. This study supports the feasibility of oral colon-targeted drug delivery for proteins, therapeutic polypeptides, and functional food.
KW - Colon-targeted delivery system
KW - Liver hydrolysate
KW - Liver injury
KW - Protein delivery
KW - Traditional medicine
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U2 - 10.1016/S1773-2247(13)50071-2
DO - 10.1016/S1773-2247(13)50071-2
M3 - Article
AN - SCOPUS:84884828492
SN - 1773-2247
VL - 23
SP - 493
EP - 497
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
IS - 5
ER -