TY - JOUR
T1 - Colorectal distention induces hippocampal noradrenaline release in rats
T2 - An in vivo microdialysis study
AU - Saito, Kumi
AU - Kanazawa, Motoyori
AU - Fukudo, Shin
N1 - Funding Information:
This study was supported by the Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture (No. 11680778) and the Ministry of Health and Welfare (No. H11-Brain 003).
PY - 2002/8/23
Y1 - 2002/8/23
N2 - We tested our hypothesis that noradrenaline is released in the hippocampus by colorectal distention of rats, and that it induces pain-related behavior. Noradrenaline levels with colorectal distention were significantly higher than those with restraint stress and free moving. Abdominal contractions were induced only by colorectal distention. Our results suggest that noradrenaline levels increase in the hippocampus under colorectal distention and this may relate to behavioral changes.
AB - We tested our hypothesis that noradrenaline is released in the hippocampus by colorectal distention of rats, and that it induces pain-related behavior. Noradrenaline levels with colorectal distention were significantly higher than those with restraint stress and free moving. Abdominal contractions were induced only by colorectal distention. Our results suggest that noradrenaline levels increase in the hippocampus under colorectal distention and this may relate to behavioral changes.
KW - Brain-gut interaction
KW - Emotion
KW - Irritable bowel syndrome
KW - Microdialysis
KW - Stress
KW - Visceral perception
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U2 - 10.1016/S0006-8993(02)03007-X
DO - 10.1016/S0006-8993(02)03007-X
M3 - Article
C2 - 12144863
AN - SCOPUS:0037162970
SN - 0006-8993
VL - 947
SP - 146
EP - 149
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1
ER -