Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: A pilot study

Noriaki Iwao; Minoru Yoshida; Kiyohiko Hatake; Yoshiaki Hoshino; Shoutaro Hagiwara; Hiroshi Tomizuka; Ritsuko Shimizu; Toshiyuki Suzuki; Yusuke Furukawa; Norio Komatsu; Kazuo Muroi; Akiyoshi Miwa; Shinobu Sakamoto; Yasusada Miura

doi:10.1016/0145-2126(95)00072-0

Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: A pilot study

Noriaki Iwao, Minoru Yoshida, Kiyohiko Hatake, Yoshiaki Hoshino, Shoutaro Hagiwara, Hiroshi Tomizuka, Ritsuko Shimizu, Toshiyuki Suzuki, Yusuke Furukawa, Norio Komatsu, Kazuo Muroi, Akiyoshi Miwa, Shinobu Sakamoto, Yasusada Miura

MED - Health Sciences

Jichi Medical University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Fourteen patients with high-risk leukemia (six with relapsed AML, three with relapsed ALL, one with AML-M0, four with CML in myeloid blastic crisis) were treated with a combination chemotherapy of carboplatin (200-300 mg/m²/day) and cytosine arabinoside (100 mg/m²/day) by 24 h continuous infusion for 5-7 days. Five patients (35.7%) achieved complete remission including two patients complicated with myelofibrosis (one with AML-M0 and one with CML in myelo-megakaryocytic crisis). Thirteen patients had nausea and vomiting, five patients had severe, prolonged neutropenia for which it was necessary to administer granulocyte colony-stimulating factor and six patients had severe thrombocytopenia. We concluded that this regimen is effective for the treatment of high-risk leukemia.

Original language	English
Pages (from-to)	899-903
Number of pages	5
Journal	Leukemia Research
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/0145-2126(95)00072-0
Publication status	Published - 1995 Dec

Keywords

Carboplatin
continuous infusion
cytosine arabinoside
high-risk leukemia
prolonged neutropenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0145-2126(95)00072-0

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title = "Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: A pilot study",

abstract = "Fourteen patients with high-risk leukemia (six with relapsed AML, three with relapsed ALL, one with AML-M0, four with CML in myeloid blastic crisis) were treated with a combination chemotherapy of carboplatin (200-300 mg/m2/day) and cytosine arabinoside (100 mg/m2/day) by 24 h continuous infusion for 5-7 days. Five patients (35.7%) achieved complete remission including two patients complicated with myelofibrosis (one with AML-M0 and one with CML in myelo-megakaryocytic crisis). Thirteen patients had nausea and vomiting, five patients had severe, prolonged neutropenia for which it was necessary to administer granulocyte colony-stimulating factor and six patients had severe thrombocytopenia. We concluded that this regimen is effective for the treatment of high-risk leukemia.",

keywords = "Carboplatin, continuous infusion, cytosine arabinoside, high-risk leukemia, prolonged neutropenia",

author = "Noriaki Iwao and Minoru Yoshida and Kiyohiko Hatake and Yoshiaki Hoshino and Shoutaro Hagiwara and Hiroshi Tomizuka and Ritsuko Shimizu and Toshiyuki Suzuki and Yusuke Furukawa and Norio Komatsu and Kazuo Muroi and Akiyoshi Miwa and Shinobu Sakamoto and Yasusada Miura",

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doi = "10.1016/0145-2126(95)00072-0",

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T1 - Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia

T2 - A pilot study

AU - Iwao, Noriaki

AU - Yoshida, Minoru

AU - Hatake, Kiyohiko

AU - Hoshino, Yoshiaki

AU - Hagiwara, Shoutaro

AU - Tomizuka, Hiroshi

AU - Shimizu, Ritsuko

AU - Suzuki, Toshiyuki

AU - Furukawa, Yusuke

AU - Komatsu, Norio

AU - Muroi, Kazuo

AU - Miwa, Akiyoshi

AU - Sakamoto, Shinobu

AU - Miura, Yasusada

PY - 1995/12

Y1 - 1995/12

N2 - Fourteen patients with high-risk leukemia (six with relapsed AML, three with relapsed ALL, one with AML-M0, four with CML in myeloid blastic crisis) were treated with a combination chemotherapy of carboplatin (200-300 mg/m2/day) and cytosine arabinoside (100 mg/m2/day) by 24 h continuous infusion for 5-7 days. Five patients (35.7%) achieved complete remission including two patients complicated with myelofibrosis (one with AML-M0 and one with CML in myelo-megakaryocytic crisis). Thirteen patients had nausea and vomiting, five patients had severe, prolonged neutropenia for which it was necessary to administer granulocyte colony-stimulating factor and six patients had severe thrombocytopenia. We concluded that this regimen is effective for the treatment of high-risk leukemia.

AB - Fourteen patients with high-risk leukemia (six with relapsed AML, three with relapsed ALL, one with AML-M0, four with CML in myeloid blastic crisis) were treated with a combination chemotherapy of carboplatin (200-300 mg/m2/day) and cytosine arabinoside (100 mg/m2/day) by 24 h continuous infusion for 5-7 days. Five patients (35.7%) achieved complete remission including two patients complicated with myelofibrosis (one with AML-M0 and one with CML in myelo-megakaryocytic crisis). Thirteen patients had nausea and vomiting, five patients had severe, prolonged neutropenia for which it was necessary to administer granulocyte colony-stimulating factor and six patients had severe thrombocytopenia. We concluded that this regimen is effective for the treatment of high-risk leukemia.

KW - Carboplatin

KW - continuous infusion

KW - cytosine arabinoside

KW - high-risk leukemia

KW - prolonged neutropenia

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Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: A pilot study

Abstract

Keywords

UN SDGs

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