Combinatorial library synthesis of two- and three-ring benzenoid amides on solid support

Akira Mori; Issei Akahoshi; Masashi Hashimoto; Takayuki Doi; Takashi Takahashi

doi:10.1016/j.tetlet.2003.11.043

Combinatorial library synthesis of two- and three-ring benzenoid amides on solid support

Akira Mori, Issei Akahoshi, Masashi Hashimoto, Takayuki Doi, Takashi Takahashi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A liquid crystalline library of 100 molecules with three benzene rings and 18 molecules with two benzene rings was synthesized on solid support by means of benzoylation or acylation and palladium(0)-catalyzed carbonylation of a secondary amine obtained by a reductive amination of 4-iodoaniline and a backbone amide linker. The conversion and purity of the final products are high enough to investigate the mesomorphic properties.

Original language	English
Pages (from-to)	813-815
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2003.11.043
Publication status	Published - 2004 Jan 19

Keywords

Benzenoid liquid crystals
Pd-catalyzed carbonylation
Solid-phase synthesis

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10.1016/j.tetlet.2003.11.043

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abstract = "A liquid crystalline library of 100 molecules with three benzene rings and 18 molecules with two benzene rings was synthesized on solid support by means of benzoylation or acylation and palladium(0)-catalyzed carbonylation of a secondary amine obtained by a reductive amination of 4-iodoaniline and a backbone amide linker. The conversion and purity of the final products are high enough to investigate the mesomorphic properties.",

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author = "Akira Mori and Issei Akahoshi and Masashi Hashimoto and Takayuki Doi and Takashi Takahashi",

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T1 - Combinatorial library synthesis of two- and three-ring benzenoid amides on solid support

AU - Mori, Akira

AU - Akahoshi, Issei

AU - Hashimoto, Masashi

AU - Doi, Takayuki

AU - Takahashi, Takashi

PY - 2004/1/19

Y1 - 2004/1/19

N2 - A liquid crystalline library of 100 molecules with three benzene rings and 18 molecules with two benzene rings was synthesized on solid support by means of benzoylation or acylation and palladium(0)-catalyzed carbonylation of a secondary amine obtained by a reductive amination of 4-iodoaniline and a backbone amide linker. The conversion and purity of the final products are high enough to investigate the mesomorphic properties.

AB - A liquid crystalline library of 100 molecules with three benzene rings and 18 molecules with two benzene rings was synthesized on solid support by means of benzoylation or acylation and palladium(0)-catalyzed carbonylation of a secondary amine obtained by a reductive amination of 4-iodoaniline and a backbone amide linker. The conversion and purity of the final products are high enough to investigate the mesomorphic properties.

KW - Benzenoid liquid crystals

KW - Pd-catalyzed carbonylation

KW - Solid-phase synthesis

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DO - 10.1016/j.tetlet.2003.11.043

M3 - Article

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SN - 0040-4039

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SP - 813

EP - 815

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Combinatorial library synthesis of two- and three-ring benzenoid amides on solid support

Abstract

Keywords

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