Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy

Mitsutoshi Munakata; Rie Kato; Hiroyuki Yokoyama; Kazuhiro Haginoya; Yoshiko Tanaka; Jun Kayaba; Taku Kato; Reiko Takayanagi; Hiroko Endo; Ryuiti Hasegawa; Yutaka Ejima; Kunihiko Hoshi; Kazuie Iinuma

doi:10.1016/S0387-7604(00)00169-8

Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy

Mitsutoshi Munakata, Rie Kato, Hiroyuki Yokoyama, Kazuhiro Haginoya, Yoshiko Tanaka, Jun Kayaba, Taku Kato, Reiko Takayanagi, Hiroko Endo, Ryuiti Hasegawa, Yutaka Ejima, Kunihiko Hoshi, Kazuie Iinuma

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73 Citations (Scopus)

Abstract

Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35°C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	373-377
Number of pages	5
Journal	Brain and Development
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/S0387-7604(00)00169-8
Publication status	Published - 2000

Keywords

Corticosteroid
Hypothermia
Influenza A virus
Ulinastatin

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10.1016/S0387-7604(00)00169-8

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abstract = "Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35°C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy. (C) 2000 Elsevier Science B.V.",

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T1 - Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy

AU - Munakata, Mitsutoshi

AU - Kato, Rie

AU - Yokoyama, Hiroyuki

AU - Haginoya, Kazuhiro

AU - Tanaka, Yoshiko

AU - Kayaba, Jun

AU - Kato, Taku

AU - Takayanagi, Reiko

AU - Endo, Hiroko

AU - Hasegawa, Ryuiti

AU - Ejima, Yutaka

AU - Hoshi, Kunihiko

AU - Iinuma, Kazuie

PY - 2000

Y1 - 2000

N2 - Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35°C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy. (C) 2000 Elsevier Science B.V.

AB - Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35°C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy. (C) 2000 Elsevier Science B.V.

KW - Corticosteroid

KW - Hypothermia

KW - Influenza A virus

KW - Ulinastatin

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JO - Brain and Development

JF - Brain and Development

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ER -

Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy

Abstract

Keywords

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