Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy

Mitsutoshi Munakata, Rie Kato, Hiroyuki Yokoyama, Kazuhiro Haginoya, Yoshiko Tanaka, Jun Kayaba, Taku Kato, Reiko Takayanagi, Hiroko Endo, Ryuiti Hasegawa, Yutaka Ejima, Kunihiko Hoshi, Kazuie Iinuma

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73 Citations (Scopus)


Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35°C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalBrain and Development
Issue number6
Publication statusPublished - 2000


  • Corticosteroid
  • Hypothermia
  • Influenza A virus
  • Ulinastatin


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