Comparative Genomic Hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma

Yoshifumi Komoike; Yasuhiro Tamaki; Isao Sakita; Naohiro Tomita; Masayuki Ohue; Mitsugu Sekimoto; Michihiko Miyazaki; Masao Kadota; Norikazu Masuda; Masaru Ooka; Tadashi Ohnishi; Yoshiaki Nakano; Takazumi Kozaki; Tetsuro Kobayashi; Nariaki Matsuura; Takayuki Ikeda; Akira Horii; Morito Monden

doi:10.3892/ijo.14.6.1157

Comparative Genomic Hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma

Yoshifumi Komoike, Yasuhiro Tamaki, Isao Sakita, Naohiro Tomita, Masayuki Ohue, Mitsugu Sekimoto, Michihiko Miyazaki, Masao Kadota, Norikazu Masuda, Masaru Ooka, Tadashi Ohnishi, Yoshiaki Nakano, Takazumi Kozaki, Tetsuro Kobayashi, Nariaki Matsuura, Takayuki Ikeda, Akira Horii, Morito Monden

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Anaplastic thyroid cancer (ATC) is one of the malignant tumors with the poor prognosis that is thought to arise from well-differentiated thyroid cancer (DTC). To investigate the molecular mechanism of ATC, we studied genomic alterations of eight ATC cell lines and three DTC cell lines by means of the comparative genomic hybridization (CGH) method. Loss of 16p was observed in five of eight ATC cell lines (62.5%), but none of the three DTC cell lines showed loss of this chromosome arm. It is notable that loss of 18q [7/8 of ATC (87.5%), 2/3 of DTC (67%)] and gain of 20q [5/8 of ATC (62.5%), 3/3 of DTC (100%)] were frequently seen in both histologic types. Our results suggest that there is a gene in 16p that is closely associated with transformation from well-differentiated thyroid cancer to anaplastic cancer.

Original language	English
Pages (from-to)	1157-1162
Number of pages	6
Journal	International journal of oncology
Volume	14
Issue number	6
DOIs	https://doi.org/10.3892/ijo.14.6.1157
Publication status	Published - 1999 Jun
Externally published	Yes

Keywords

Anaplastic thyroid cancer
Comparative genomic hybridization
Genomic imbalance

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ijo.14.6.1157

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Komoike, Y., Tamaki, Y., Sakita, I., Tomita, N., Ohue, M., Sekimoto, M., Miyazaki, M., Kadota, M., Masuda, N., Ooka, M., Ohnishi, T., Nakano, Y., Kozaki, T., Kobayashi, T., Matsuura, N., Ikeda, T., Horii, A., & Monden, M. (1999). Comparative Genomic Hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma. International journal of oncology, 14(6), 1157-1162. https://doi.org/10.3892/ijo.14.6.1157

Komoike, Y, Tamaki, Y, Sakita, I, Tomita, N, Ohue, M, Sekimoto, M, Miyazaki, M, Kadota, M, Masuda, N, Ooka, M, Ohnishi, T, Nakano, Y, Kozaki, T, Kobayashi, T, Matsuura, N, Ikeda, T, Horii, A & Monden, M 1999, 'Comparative Genomic Hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma', International journal of oncology, vol. 14, no. 6, pp. 1157-1162. https://doi.org/10.3892/ijo.14.6.1157

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abstract = "Anaplastic thyroid cancer (ATC) is one of the malignant tumors with the poor prognosis that is thought to arise from well-differentiated thyroid cancer (DTC). To investigate the molecular mechanism of ATC, we studied genomic alterations of eight ATC cell lines and three DTC cell lines by means of the comparative genomic hybridization (CGH) method. Loss of 16p was observed in five of eight ATC cell lines (62.5%), but none of the three DTC cell lines showed loss of this chromosome arm. It is notable that loss of 18q [7/8 of ATC (87.5%), 2/3 of DTC (67%)] and gain of 20q [5/8 of ATC (62.5%), 3/3 of DTC (100%)] were frequently seen in both histologic types. Our results suggest that there is a gene in 16p that is closely associated with transformation from well-differentiated thyroid cancer to anaplastic cancer.",

keywords = "Anaplastic thyroid cancer, Comparative genomic hybridization, Genomic imbalance",

author = "Yoshifumi Komoike and Yasuhiro Tamaki and Isao Sakita and Naohiro Tomita and Masayuki Ohue and Mitsugu Sekimoto and Michihiko Miyazaki and Masao Kadota and Norikazu Masuda and Masaru Ooka and Tadashi Ohnishi and Yoshiaki Nakano and Takazumi Kozaki and Tetsuro Kobayashi and Nariaki Matsuura and Takayuki Ikeda and Akira Horii and Morito Monden",

year = "1999",

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doi = "10.3892/ijo.14.6.1157",

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T1 - Comparative Genomic Hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma

AU - Komoike, Yoshifumi

AU - Tamaki, Yasuhiro

AU - Sakita, Isao

AU - Tomita, Naohiro

AU - Ohue, Masayuki

AU - Sekimoto, Mitsugu

AU - Miyazaki, Michihiko

AU - Kadota, Masao

AU - Masuda, Norikazu

AU - Ooka, Masaru

AU - Ohnishi, Tadashi

AU - Nakano, Yoshiaki

AU - Kozaki, Takazumi

AU - Kobayashi, Tetsuro

AU - Matsuura, Nariaki

AU - Ikeda, Takayuki

AU - Horii, Akira

AU - Monden, Morito

PY - 1999/6

Y1 - 1999/6

N2 - Anaplastic thyroid cancer (ATC) is one of the malignant tumors with the poor prognosis that is thought to arise from well-differentiated thyroid cancer (DTC). To investigate the molecular mechanism of ATC, we studied genomic alterations of eight ATC cell lines and three DTC cell lines by means of the comparative genomic hybridization (CGH) method. Loss of 16p was observed in five of eight ATC cell lines (62.5%), but none of the three DTC cell lines showed loss of this chromosome arm. It is notable that loss of 18q [7/8 of ATC (87.5%), 2/3 of DTC (67%)] and gain of 20q [5/8 of ATC (62.5%), 3/3 of DTC (100%)] were frequently seen in both histologic types. Our results suggest that there is a gene in 16p that is closely associated with transformation from well-differentiated thyroid cancer to anaplastic cancer.

AB - Anaplastic thyroid cancer (ATC) is one of the malignant tumors with the poor prognosis that is thought to arise from well-differentiated thyroid cancer (DTC). To investigate the molecular mechanism of ATC, we studied genomic alterations of eight ATC cell lines and three DTC cell lines by means of the comparative genomic hybridization (CGH) method. Loss of 16p was observed in five of eight ATC cell lines (62.5%), but none of the three DTC cell lines showed loss of this chromosome arm. It is notable that loss of 18q [7/8 of ATC (87.5%), 2/3 of DTC (67%)] and gain of 20q [5/8 of ATC (62.5%), 3/3 of DTC (100%)] were frequently seen in both histologic types. Our results suggest that there is a gene in 16p that is closely associated with transformation from well-differentiated thyroid cancer to anaplastic cancer.

KW - Anaplastic thyroid cancer

KW - Comparative genomic hybridization

KW - Genomic imbalance

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Comparative Genomic Hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma

Abstract

Keywords

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UN SDGs

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