TY - JOUR
T1 - Comparison of bone regeneration between octacalcium phosphate/collagen composite and β-tricalcium phosphate in canine calvarial defect
AU - Tanuma, Yuji
AU - Matsui, Keiko
AU - Kawai, Tadashi
AU - Matsui, Aritsune
AU - Suzuki, Osamu
AU - Kamakura, Shinji
AU - Echigo, Seishi
N1 - Funding Information:
Supported in part by Grants-in-Aid ( 20300165 , 21592568 , and 19390490 ) from the Ministry of Education, Science, Sports, and Culture of Japan and the Hiromi Medical Research Foundation . O. Suzuki and S. Kamakura have applied for a patent of OCP/Col in Japan.
PY - 2013/1
Y1 - 2013/1
N2 - Objective: The present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP). Study Design: A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation. Results: Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P <.05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP. Conclusions: These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes.
AB - Objective: The present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP). Study Design: A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation. Results: Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P <.05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP. Conclusions: These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes.
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U2 - 10.1016/j.oooo.2011.12.029
DO - 10.1016/j.oooo.2011.12.029
M3 - Article
C2 - 22901651
AN - SCOPUS:84870866523
SN - 2212-4403
VL - 115
SP - 9
EP - 17
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 1
ER -