Comparison of interleukin-17- producing cells in different clinical types of alopecia areata

Genichi Tojo; Taku Fujimura; Mitsuko Kawano; Kouetsu Ogasawara; Yumi Kambayashi; Sadanori Furudate; Masato Mizuashi; Setsuya Aiba

doi:10.1159/000353159

Comparison of interleukin-17- producing cells in different clinical types of alopecia areata

Genichi Tojo, Taku Fujimura, Mitsuko Kawano, Kouetsu Ogasawara, Yumi Kambayashi, Sadanori Furudate, Masato Mizuashi, Setsuya Aiba

Tohoku University

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). In this report, we employed immunohistochemical staining for IL-17-producing cells, as well as interferon-γ-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA.

Original language	English
Pages (from-to)	78-82
Number of pages	5
Journal	Dermatology
Volume	227
Issue number	1
DOIs	https://doi.org/10.1159/000353159
Publication status	Published - 2013 Oct

Keywords

Acute diffuse and total alopecia
Alopecia areata
Interferon-γ
Interleukin-17

Access to Document

10.1159/000353159

Cite this

@article{1f0090ea9dc04488b2a54a7ea270f638,

title = "Comparison of interleukin-17- producing cells in different clinical types of alopecia areata",

abstract = "T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). In this report, we employed immunohistochemical staining for IL-17-producing cells, as well as interferon-γ-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA.",

keywords = "Acute diffuse and total alopecia, Alopecia areata, Interferon-γ, Interleukin-17",

author = "Genichi Tojo and Taku Fujimura and Mitsuko Kawano and Kouetsu Ogasawara and Yumi Kambayashi and Sadanori Furudate and Masato Mizuashi and Setsuya Aiba",

year = "2013",

month = oct,

doi = "10.1159/000353159",

language = "English",

volume = "227",

pages = "78--82",

journal = "Dermatology",

issn = "1018-8665",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Comparison of interleukin-17- producing cells in different clinical types of alopecia areata

AU - Tojo, Genichi

AU - Fujimura, Taku

AU - Kawano, Mitsuko

AU - Ogasawara, Kouetsu

AU - Kambayashi, Yumi

AU - Furudate, Sadanori

AU - Mizuashi, Masato

AU - Aiba, Setsuya

PY - 2013/10

Y1 - 2013/10

N2 - T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). In this report, we employed immunohistochemical staining for IL-17-producing cells, as well as interferon-γ-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA.

AB - T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). In this report, we employed immunohistochemical staining for IL-17-producing cells, as well as interferon-γ-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA.

KW - Acute diffuse and total alopecia

KW - Alopecia areata

KW - Interferon-γ

KW - Interleukin-17

UR - http://www.scopus.com/inward/record.url?scp=84885632529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885632529&partnerID=8YFLogxK

U2 - 10.1159/000353159

DO - 10.1159/000353159

M3 - Article

C2 - 24008930

AN - SCOPUS:84885632529

SN - 1018-8665

VL - 227

SP - 78

EP - 82

JO - Dermatology

JF - Dermatology

IS - 1

ER -

Comparison of interleukin-17- producing cells in different clinical types of alopecia areata

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this