Comparison of Long-Term Follow-Up of Electrocardiographic Features in Brugada Syndrome Between the SCN5A-Positive Probands and the SCN5A-Negative Probands

Miki Yokokawa, Takashi Noda, Hideo Okamura, Kazuhiro Satomi, Kazuhiro Suyama, Takashi Kurita, Naohiko Aihara, Shiro Kamakura, Wataru Shimizu

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

To investigate changes of electrocardiographic parameters with aging and their relation to the presence of SCN5A mutation in probands with Brugada syndrome (BS), we measured several electrocardiographic parameters prospectively during long-term follow-up (10 ± 5 years) in 8 BS probands with SCN5A mutation (SCN5A-positive group, all men; age 46 ± 10 years) and 36 BS probands without SCN5A mutation (SCN5A-negative group, all men; age 46 ± 13 years). Throughout the follow-up period, depolarization parameters, such as P-wave (lead II), QRS (leads II, V2, V5), S-wave durations (leads II, V5), and PQ interval (leads II) were all significantly longer and S-wave amplitude (II, V5) was significantly deeper in the SCN5A-positive group than in the SCN5A-negative group. The SCN5A-positive group showed a significantly longer corrected QT interval (lead V2) and higher ST amplitude (lead V2) than those in the SCN5A-negative group. The depolarization parameters increased with aging during the follow-up period in both groups; however, the PQ interval (lead II) and QRS duration (lead V2) were prolonged more prominently and the QRS axis deviated more to the left with aging in the SCN5A-positive group than in the SCN5A-negative group. In conclusion, conduction slowing was more marked and more progressively accentuated in Brugada probands with SCN5A mutation than in those without SCN5A mutation.

Original languageEnglish
Pages (from-to)649-655
Number of pages7
JournalAmerican Journal of Cardiology
Volume100
Issue number4
DOIs
Publication statusPublished - 2007 Aug 15

Fingerprint

Dive into the research topics of 'Comparison of Long-Term Follow-Up of Electrocardiographic Features in Brugada Syndrome Between the SCN5A-Positive Probands and the SCN5A-Negative Probands'. Together they form a unique fingerprint.

Cite this