Complete Stereochemical Assignment of Campechic Acids A and B

Ruri Isaka, Linkai Yu, Makoto Sasaki, Yasuhiro Igarashi, Haruhiko Fuwa

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Campechic acids A and B are anti-invasive polyketide antibiotics isolated from Streptomyces sp. CHI93 strain. Herein we describe stereoselective synthesis of the C-16-C-30 fragment of campechic acids A and B via a biosynthesis-inspired epoxide-opening cascade and its NMR spectroscopic comparison with the authentic degradation product, resulting in configurational assignment of the C-21, C-24, C-25, and C-28 stereogenic centers and reassignment of the C-18 stereogenic center.

Original languageEnglish
Pages (from-to)3638-3647
Number of pages10
JournalJournal of Organic Chemistry
Issue number9
Publication statusPublished - 2016 May 6


Dive into the research topics of 'Complete Stereochemical Assignment of Campechic Acids A and B'. Together they form a unique fingerprint.

Cite this