TY - JOUR
T1 - Comprehensive analysis of tissue-specific markers involved in periodontal ligament development
AU - Saito, Masahiro
AU - Nishida, Eisaku
AU - Yoneda, Toshiyuki
N1 - Funding Information:
We would like to thank Drs. Nobuyoshi Shimizu and Takashi Sasaki for assistance with establishing the gene expression profiling database. We are also grateful to Dr. Toshio Teranaka and all the members of the Department of Molecular and Cellular Biochem-istry, Osaka University School of Dentistry. This work was supported by a Grant－in－Aid for a High－ Tech Research Center Project from the Ministry of Education, Culture, Sports, Science and Technology （MEXT）of Japan, the AGU High－Tech Research Cen-ter Project, the 2003 Multidisciplinary Research Pro-ject from MEXT, and grants from MEXT.
PY - 2008/8
Y1 - 2008/8
N2 - The periodontal ligament (PDL) is a tendon/ligament-like fibrous tissue that connects the tooth root surface and the alveolar bone. General interest has been expressed in PDL development as a model for connective tissue formation because of its ability to adapt to mechanical loading. PDL cell has its origin in the dental follicle (DF) cell, and it begins to differentiate during tooth root development. During apical development of the tooth root, PDL progenitors in DF differentiate into PDL cells to form the PDL; however, the molecular mechanisms of PDL development have not yet been clarified, as PDL lineage-specific markers are not available. We recently established a transcriptome database for the human PDL (KK-Periome database), and screened the genes specifically expressed during PDL development. Initial screening of the database allowed us to identify F-spondin and tenascin-N, which are restricted to DF and PDL cells, respectively. Thus, these could serve as PDL lineage-specific markers that would be useful for investigating the molecular mechanisms of PDL development.
AB - The periodontal ligament (PDL) is a tendon/ligament-like fibrous tissue that connects the tooth root surface and the alveolar bone. General interest has been expressed in PDL development as a model for connective tissue formation because of its ability to adapt to mechanical loading. PDL cell has its origin in the dental follicle (DF) cell, and it begins to differentiate during tooth root development. During apical development of the tooth root, PDL progenitors in DF differentiate into PDL cells to form the PDL; however, the molecular mechanisms of PDL development have not yet been clarified, as PDL lineage-specific markers are not available. We recently established a transcriptome database for the human PDL (KK-Periome database), and screened the genes specifically expressed during PDL development. Initial screening of the database allowed us to identify F-spondin and tenascin-N, which are restricted to DF and PDL cells, respectively. Thus, these could serve as PDL lineage-specific markers that would be useful for investigating the molecular mechanisms of PDL development.
KW - Development
KW - EST
KW - Extracellular matrix
KW - Periodontal ligament
KW - Transcriptome
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U2 - 10.2330/joralbiosci.50.175
DO - 10.2330/joralbiosci.50.175
M3 - Review article
AN - SCOPUS:55149122426
SN - 1349-0079
VL - 50
SP - 175
EP - 182
JO - Journal of Oral Biosciences
JF - Journal of Oral Biosciences
IS - 3
ER -