TY - JOUR
T1 - Computational study on thrombus formation regulated by platelet glycoprotein and blood flow shear
AU - Kamada, Hiroki
AU - Imai, Yohsuke
AU - Nakamura, Masanori
AU - Ishikawa, Takuji
AU - Yamaguchi, Takami
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Scientific Research (S) (No. 23220012 ), and by a Grant-in-Aid for Young Scientists (A) (No. 24680048 ) from the JSPS .
Funding Information:
Grant sponsor: Japan Society for the Promotion of Science (JSPS) .
PY - 2013/9
Y1 - 2013/9
N2 - Thrombogenesis results from the interaction between glycoprotein receptors and their ligands, although a thrombus is affected by multiple factors such as blood flow, platelet interactions, and changes in ligand characteristics. In this study, we propose a platelet adhesion and aggregation model, focusing on the interaction between the glycoprotein receptor and its ligand. First, we conducted thrombogenesis simulations to compare physiological and pathological conditions. The results suggested that simulations of thrombogenesis differed in distribution, volume, and stability of the thrombus based on disorders of platelet adhesion, aggregation, and the activation. For example, distribution and volume were affected by the activation of GPIIb/IIIa with a GPIb/IX/V deficiency. The thrombus was also unstable, but formed from the upstream side of the injured site, with a GPIIb/IIIa deficiency. Second, we investigated thrombogenesis enhanced by the shear-induced platelet aggregation (SIPA) mechanism. The results demonstrated that the degree of SIPA decreased gradually with thrombus growth in a straight vessel. This result suggests that SIPA is a key hemostasis mechanism in an injured healthy arteriole, although it can lead to the formation of an occlusive thrombus in stenosed vessels.
AB - Thrombogenesis results from the interaction between glycoprotein receptors and their ligands, although a thrombus is affected by multiple factors such as blood flow, platelet interactions, and changes in ligand characteristics. In this study, we propose a platelet adhesion and aggregation model, focusing on the interaction between the glycoprotein receptor and its ligand. First, we conducted thrombogenesis simulations to compare physiological and pathological conditions. The results suggested that simulations of thrombogenesis differed in distribution, volume, and stability of the thrombus based on disorders of platelet adhesion, aggregation, and the activation. For example, distribution and volume were affected by the activation of GPIIb/IIIa with a GPIb/IX/V deficiency. The thrombus was also unstable, but formed from the upstream side of the injured site, with a GPIIb/IIIa deficiency. Second, we investigated thrombogenesis enhanced by the shear-induced platelet aggregation (SIPA) mechanism. The results demonstrated that the degree of SIPA decreased gradually with thrombus growth in a straight vessel. This result suggests that SIPA is a key hemostasis mechanism in an injured healthy arteriole, although it can lead to the formation of an occlusive thrombus in stenosed vessels.
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U2 - 10.1016/j.mvr.2013.05.006
DO - 10.1016/j.mvr.2013.05.006
M3 - Article
C2 - 23743249
AN - SCOPUS:84883146780
SN - 0026-2862
VL - 89
SP - 95
EP - 106
JO - Microvascular Research
JF - Microvascular Research
ER -