Concise synthesis of PM-94128 and Y-05460M-A

Masaru Enomoto, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


(Chemical Equation Presented) The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-L-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-L-valine by the same approach, which enabled its stereochemical determination.

Original languageEnglish
Pages (from-to)7566-7569
Number of pages4
JournalJournal of Organic Chemistry
Issue number19
Publication statusPublished - 2009 Oct 2


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