Confusion in the nomenclature of synaptotagmins V and IX: Which is which?

Mitsunori Fukuda, Ronit Sagi-Eisenberg

Research output: Contribution to journalShort surveypeer-review

4 Citations (Scopus)


Synaptotagmins (Syts) are a large family of evolutionarily conserved proteins that comprise an N-terminal single transmembrane domain and C-terminal cytoplasmic tandem C2 Ca2+/phospholipid-binding motifs. Fifteen distinct Syt isoforms (Syts I-XV) are present in mice and humans, and some of them, but not all, have been shown to regulate Ca2+-dependent vesicular exocytosis, presumably by serving as a Ca2+-sensor. The nomenclature of two Syt family members, Syt V and Syt IX, both of which are present on dense-core vesicles in certain endocrine cells, is very confusing in the literature, because two different Syt V sequences were reported at the same time by several groups, and each of them is often referred to as Syt IX. In this mini-review we describe the literature on the identification of Syt V and Syt IX and their role in vesicular exocytosis to clarify the confusion in Syt V/IX nomenclature.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalCalcium Binding Proteins
Issue number1
Publication statusPublished - 2008 Jan


  • Ca-sensor
  • Dense-core vesicle exocytosis
  • Endocrine cells
  • Mast cells
  • Synaptotagmin

ASJC Scopus subject areas

  • Structural Biology
  • Cell Biology


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