Constant-current-mode LAPS (CLAPS) for the detection of penicillin

Tatsuo Yoshinobu, Holger Ecken, Arshak Poghossian, Anette Simonis, Hiroshi Iwasaki, Hans Lüth, Michael J. Schöning

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


A software feedback control system for the constant-current-mode operation of the light-addressable potentiometric sensor (LAPS) was developed. The constant-current-mode LAPS (CLAPS) is suitable for online monitoring and recording of changes in the pH value or the ion concentration. An enzyme LAPS was fabricated by adsorptive immobilization of penicillinase on the pH-sensitive layer of Ta2O5. This sensor was operated in the constant-current-mode and the detection limit for penicillin G was found to be at least as low as 100 μM.

Original languageEnglish
Pages (from-to)733-736
Number of pages4
Issue number8-9
Publication statusPublished - 2001


  • Chemical sensor
  • Light-addressable potentiometric sensor (LAPS)
  • Penicillin
  • TaO


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