Because nivolumab significantly prolongs survival in patients with metastatic melanoma, enhancing its antitumor immune response is of great interest to dermato-oncologists. In this report, we describe two cases of metastatic melanoma successfully treated with nivolumab in combination with contact immunotherapy, using contact sensitizing agents, such as squaric acid dibutylester and diphencyprone. In addition, immunohistochemical staining supported one of the possible mechanisms of this combination therapy. Our present cases suggested a possible therapy for metastatic melanoma using nivolumab in combination with contact immunotherapy.
|Number of pages||4|
|Journal||Journal of Dermatology|
|Publication status||Published - 2016 Jun 1|
- Contact immunotherapy
- Immunohistochemical staining
- PD-1/PD-L1 blockade
ASJC Scopus subject areas