Contamination of 2-deoxy-2-[18F]fluoro-d-mannose in the 2-deoxy-2-[18F]fluoro-d-glucose preparations synthesized from [18F]acetyl hypofluorite and [18F]F2

Kiichi Ishiwata; Tatsuo Ido; Hiroaki Nakanishi; Ren Iwata

doi:10.1016/0883-2889(87)90100-6

Contamination of 2-deoxy-2-[¹⁸F]fluoro-d-mannose in the 2-deoxy-2-[¹⁸F]fluoro-d-glucose preparations synthesized from [¹⁸F]acetyl hypofluorite and [¹⁸F]F₂

Kiichi Ishiwata, Tatsuo Ido, Hiroaki Nakanishi, Ren Iwata

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The presence of 2-deoxy-2-[¹⁸F]fluoro-d-mannose ([¹⁸F]FDM) in 2-deoxy-2-[¹⁸F]fluoro-d-glucose ([¹⁸F]FDG) prepared by the reaction of 3,4,6-tri-O-acetyl-d-glucal (TAG) with [¹⁸F]acetyl hypofluorite ([¹⁸F]CH₃COOF) or [¹⁸F]F₂ was quantified by radio HPLC analysis of reacetylated [¹⁸F]FDG. The solvent effects on the stereoselectivity of the reaction of TAG with [¹⁸F]CH₃COOF were examined in six kinds of solvent. Reaction of TAG with [¹⁸F]CH₃COOF in Freon-11 results in the least contamination of [¹⁸F]FDM (4-5%). The presence of [¹⁸F]FDM in the [¹⁸F]FDG prepared from TAG with [¹⁸F]F₂ was also indicated, but by careful chromatographic separation of hexopyranosyl difluorides the amount was reduced to nearly that resulting from the [¹⁸F]CH₃COOF method.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/0883-2889(87)90100-6
Publication status	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Radiation
Engineering(all)

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10.1016/0883-2889(87)90100-6

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Contamination of 2-deoxy-2-[¹⁸F]fluoro-d-mannose in the 2-deoxy-2-[¹⁸F]fluoro-d-glucose preparations synthesized from [¹⁸F]acetyl hypofluorite and [¹⁸F]F₂. / Ishiwata, Kiichi; Ido, Tatsuo; Nakanishi, Hiroaki et al.
In: International Journal of Radiation Applications and Instrumentation. Part, Vol. 38, No. 6, 1987, p. 463-466.

Research output: Contribution to journal › Article › peer-review

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title = "Contamination of 2-deoxy-2-[18F]fluoro-d-mannose in the 2-deoxy-2-[18F]fluoro-d-glucose preparations synthesized from [18F]acetyl hypofluorite and [18F]F2",

abstract = "The presence of 2-deoxy-2-[18F]fluoro-d-mannose ([18F]FDM) in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) prepared by the reaction of 3,4,6-tri-O-acetyl-d-glucal (TAG) with [18F]acetyl hypofluorite ([18F]CH3COOF) or [18F]F2 was quantified by radio HPLC analysis of reacetylated [18F]FDG. The solvent effects on the stereoselectivity of the reaction of TAG with [18F]CH3COOF were examined in six kinds of solvent. Reaction of TAG with [18F]CH3COOF in Freon-11 results in the least contamination of [18F]FDM (4-5%). The presence of [18F]FDM in the [18F]FDG prepared from TAG with [18F]F2 was also indicated, but by careful chromatographic separation of hexopyranosyl difluorides the amount was reduced to nearly that resulting from the [18F]CH3COOF method.",

author = "Kiichi Ishiwata and Tatsuo Ido and Hiroaki Nakanishi and Ren Iwata",

year = "1987",

doi = "10.1016/0883-2889(87)90100-6",

language = "English",

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AU - Ishiwata, Kiichi

AU - Ido, Tatsuo

AU - Nakanishi, Hiroaki

AU - Iwata, Ren

PY - 1987

Y1 - 1987

N2 - The presence of 2-deoxy-2-[18F]fluoro-d-mannose ([18F]FDM) in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) prepared by the reaction of 3,4,6-tri-O-acetyl-d-glucal (TAG) with [18F]acetyl hypofluorite ([18F]CH3COOF) or [18F]F2 was quantified by radio HPLC analysis of reacetylated [18F]FDG. The solvent effects on the stereoselectivity of the reaction of TAG with [18F]CH3COOF were examined in six kinds of solvent. Reaction of TAG with [18F]CH3COOF in Freon-11 results in the least contamination of [18F]FDM (4-5%). The presence of [18F]FDM in the [18F]FDG prepared from TAG with [18F]F2 was also indicated, but by careful chromatographic separation of hexopyranosyl difluorides the amount was reduced to nearly that resulting from the [18F]CH3COOF method.

AB - The presence of 2-deoxy-2-[18F]fluoro-d-mannose ([18F]FDM) in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) prepared by the reaction of 3,4,6-tri-O-acetyl-d-glucal (TAG) with [18F]acetyl hypofluorite ([18F]CH3COOF) or [18F]F2 was quantified by radio HPLC analysis of reacetylated [18F]FDG. The solvent effects on the stereoselectivity of the reaction of TAG with [18F]CH3COOF were examined in six kinds of solvent. Reaction of TAG with [18F]CH3COOF in Freon-11 results in the least contamination of [18F]FDM (4-5%). The presence of [18F]FDM in the [18F]FDG prepared from TAG with [18F]F2 was also indicated, but by careful chromatographic separation of hexopyranosyl difluorides the amount was reduced to nearly that resulting from the [18F]CH3COOF method.

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Contamination of 2-deoxy-2-[¹⁸F]fluoro-d-mannose in the 2-deoxy-2-[¹⁸F]fluoro-d-glucose preparations synthesized from [¹⁸F]acetyl hypofluorite and [¹⁸F]F₂

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