Continuous-flow synthesis of vitamin D3

Shinichiro Fuse, Nobutake Tanabe, Masahito Yoshida, Hayato Yoshida, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


A highly efficient, two-stage, continuous-flow synthesis of vitamin D 3 from provitamin D3 was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.

Original languageEnglish
Pages (from-to)8722-8724
Number of pages3
JournalChemical Communications
Issue number46
Publication statusPublished - 2010 Dec 14


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