Control of designed high-order DNA conformation as a template for nano particle assembly

Yoshiharu Hatakeyama, Masahiro Minami, Satoshi Ohara, Mitsuo Umetsu, Seiichi Takami, Tadafumi Adschiri

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Highly selective base-pairing rules in DNA can be utilized as a tool for assembling nano particles. Holliday Junctions, where two different DNA double strands intersect and replace the complement strand, are an important artificial motif for forming two-dimensional "plane" conformations of DNA. In this study, we controlled the growth of the DNA "plane" conformations by changing the temperature. A set of DNA single chains were cooled from 90°C to 4°C for 10 minutes, to form the DNA "plane" conformation. The influence of the cooling procedure on the DNA conformation was observed by atomic force microscope (AFM). The DNA "plane" conformation is strongly dependent on the cooling process. Further, we assembled gold nano particle using the DNA conformation; then we observed the assembly of gold nano particle on the DNA conformation by transmission electron microscopy (TEM).

Original languageEnglish
Pages (from-to)617-622
Number of pages6
Issue number12
Publication statusPublished - 2004 Dec


  • Assembly
  • DNA
  • Nano particles

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics


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