Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis

J. Hui, A. Oka, G. Tamiya, M. Tomizawa, J. K. Kulski, W. J. Penhale, G. K. Tay, M. Iizuka, A. Ozawa, H. Inoko

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


In order to examine the relationship between corneodesmosin (CDSN) and psoriasis we have determined the presence of CDSN polymorphisms by DNA sequencing in (a) nine B-LCL cell lines of major histocompatibility complex ancestral haplotypes known to be associated with psoriasis vulgaris including 13.1AH, 46.1AH, 46.2 and 57.1AH, and in (b) a group of 267 unrelated individuals comprising Japanese psoriasis patients (n = 101) and Japanese subjects without the disease (n = 166). Three novel CDSN gene sequences were identified. In addition, we have classified the 18 alleles into seven main groups based on phylogeny of non-synonymous substitutions. However, we have found no statistically significant differences between the patients and the unaffected individuals in any of these groups. These findings indicate that CDSN is not a major psoriasis susceptibility gene.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalTissue Antigens
Issue number1
Publication statusPublished - 2002 Jul 1
Externally publishedYes


  • Ancestral haplotypes
  • Corneodesmosin
  • Major histocompatibility complex
  • Psoriasis vulgaris

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics


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